StackTerminal.Health

BETA

Vitamin D3

Fat-soluble vitamin with broad roles in immune function, bone health, & musculoskeletal performance.

longevityimmune

Evidence last reviewed: 04 Apr 2026

Evidence
3 records
3 recordsBest grade:Moderate
Biomarkers
Muscle Strength (1RM)Power OutputMuscle EnduranceVitamin D (25-OH)

Moderate evidence supports Vitamin D3's role in reducing respiratory infections and preventing fractures in the elderly. However, more research is needed on its impact on athletic performance, particularly in specific populations.

Prevention of acute respiratory tract infections
Children and adults (ages 0–95); 25 RCTs, n=11,321 · Systematic review and meta-analysis of individual participant data from RCTs
Moderate

Vitamin D supplementation reduced risk of acute respiratory tract infection (adjusted OR 0.88, 95% CI 0.81–0.96); greatest benefit in those with baseline deficiency (<25 nmol/L) & those receiving daily or weekly dosing rather than bolus doses.

Dose:
IPD meta-analysis; high statistical power; effect strongest in vitamin D-deficient individuals.
Vitamin D status & physical performance in athletes
Competitive and recreational athletes · Narrative review
Low

Vitamin D insufficiency is prevalent among athletes, particularly indoor athletes & those in northern latitudes in winter. Insufficiency is associated with reduced muscle strength, power, & endurance; supplementation of 2,000–6,000 IU/day recommended to maintain 25(OH)D >40 ng/mL.

Dose:
Narrative review; prevalence data robust, intervention evidence more limited.
Fracture prevention in elderly adults
Ambulatory and institutionalized elderly persons · Systematic review and meta-analysis of RCTs
Moderate

Vitamin D at 700–800 IU/day reduced hip fracture risk by 26% (RR 0.74) & any nonvertebral fracture by 23% (RR 0.77); no significant benefit was observed at 400 IU/day.

Dose:
Dose-dependent effect; 400 IU/day insufficient for fracture prevention.
Stacks containing Vitamin D3
Explore all →
endurance

Supports fluid balance during long or hot training sessions.

Sodium Citrate
500mg
Potassium Citrate
500mg
Vitamin D3
1000mg
Trending
View
daily

Maximizes health impact per dollar.

Vitamin D3
50mg
Magnesium Glycinate
400mg
New
View
dailywomens-health

Simple daily baseline to cover common gaps & support long-term health markers without fish-derived oils.

Women’s Multivitamin (generic)
1000mg
Vitamin D3
50mg
Magnesium (Glycinate)
400mg
New
View
womens-healthfertilitypreconception

This stack addresses the key nutritional & hormonal drivers of female fertility. Folate is essential for DNA synthesis & embryo development. Myo-inositol is the most evidence-backed intervention for improving ovarian function, egg quality, & cycle regularity — particularly in PCOS. CoQ10 restores mitochondrial energy in aging oocytes, & Vitex supports luteal phase adequacy through LH modulation.

Folic Acid (Folate, B9)
0mg
Myo-Inositol
4000mg
Coenzyme Q10
600mg
New
View
dailylongevity

Foundational stack aimed at mitochondrial function, insulin sensitivity, & long-term healthspan.

Omega-3 (EPA/DHA)
2000mg
Vitamin D3
50mg
Berberine HCl
1000mg
New
View
longevity

Plant-based omega-3 support for long-term cardiometabolic health.

Algal Omega-3 (EPA/DHA)
1000mg
Vitamin D3
50mg
New
View
endurance

Based on your goals & preferences, here is a starting stack you can edit.

Vitamin D3
25mg
Magnesium Citrate
1000mg
Caffeine
200mg
New
View
gutconstraints

Built from your goals & the supplement evidence library. You can edit doses & timing.

Caffeine
200mg
Beta-Alanine
3200mg
Vitamin D3
50mg
New
View
recoverysleep

Built from your goals & the supplement evidence library. You can edit doses & timing.

Caffeine
200mg
Beta-Alanine
3200mg
Vitamin D3
50mg
New
View
endurancemens-healthconstraints

This personalized supplement stack is optimized for enhancing your baseline health, supporting recovery, and boosting strength during your active training phase. With Vitamin D3 for immune support, electrolytes for hydration, fish oil for overall wellness, creatine for power, and tart cherry for recovery, this budget-friendly combination will help you maintain peak performance and promote effective recovery.

Vitamin D3
1000mg
Electrolytes (Sodium / Potassium / Magnesium blend)
1000mg
Fish Oil
2000mg
New
View
dailylongevity

High ROI basics for general health & micronutrient support.

Vitamin D3
50mg
Magnesium (Glycinate)
400mg
New
View
Community Insights
Forms & usage
How to take it

Take 700–800 IU daily, preferably with a meal.

Cholecalciferol
Preferred over D2
My notes
Sign in to keep a private note on Vitamin D3.