The evidence for glycine includes moderate-quality studies showing benefits for sleep quality and cognitive performance after sleep deprivation. While promising, more research is needed to fully understand its effects on various populations.
Daytime sleepiness & performance after sleep restrictionHealthy adults with partial sleep restriction · RCT (double-blind, placebo-controlled, crossover)Moderate
3 g glycine before bed significantly reduced daytime sleepiness, fatigue, & cognitive impairment following 25% sleep restriction; mechanism involves core body temperature reduction via SCN NMDA receptors.
Collagen synthesis / connective tissue supportRecreationally active males · RCT (mechanistic)Moderate
15 g gelatin (rich in glycine & proline, with vitamin C) before intermittent exercise doubled collagen synthesis markers (P1NP) vs. placebo; glycine is the most abundant amino acid in collagen (~33%).
Your personalized stack
Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.
PMS Calmer (Low-Stim, Cycle-Friendly)
Cycle-phase support focused on calm & sleep quality without stimulants.
Sleep Stack (Ultra-Gentle)
Improves sleep quality without heavy sedation or melatonin.
Longevity Mix (Bryan Johnson)
Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.
Stress-Resilient Training Stack
Supports training consistency under physical & mental stress.
Sleep Onset Support (Low Dose)
Supports sleep onset with minimal next-day grogginess.
Sleep & Calm Wind-Down
Supports parasympathetic activation before sleep.
Sleep & Recovery Stack
Designed to support sleep quality, parasympathetic activation, & overnight recovery without heavy sedation.
Forms & usage▾
Take 3 g of glycine before bed for best results.