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Cardiovascular Health and Antioxidant Support

Combining Grape Seed Extract with Pycnogenol can support cardiovascular health and provide antioxidant protection. Grape Seed Extract improves blood flow and reduces oxidative stress, while Pycnogenol supports vascular health and reduces inflammation.

What this is for
General support
cardiovascular, antioxidant, longevity
Why you are seeing this
Goal fit: cardiovascular, antioxidant, longevity.
What to do next
Add body metrics if you want dose previews to reflect your weight rather than the reference dose.
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Public•Built 20 Apr 2026•2 ingredients•No interactions detected
Core stack
The main ingredients doing the work.
2 key items
Grape Seed Extract (OPCs)Moderate
Daily with meals •
Grape Seed Extract improves blood flow and reduces oxidative stress.
Buy ingredient →
200mg
Antioxidant status
Moderate
Population: Patients with chronic obstructive pulmonary disease
Study type: RCT
Dose context: 200 mg typical (range: 200–400 mg) • Duration: 6 months

Enhanced antioxidant status and improved lung function.

Citation: Lu et al. (2018). Effect of Oligomeric Proanthocyanidin on the Antioxidant Status and Lung Function of Patients with Chronic Obstructive Pulmonary Disease. JCI Insight.•DOI: 10.21873/invivo.11304
Improvement in antioxidant markers and lung function.
Endothelial function improvement
Moderate
Population: Adults with cardiovascular risk factors
Study type: RCT
Dose context: 200 mg typical (range: 200–400 mg) • Duration: 12 weeks

Improved endothelial function as measured by flow-mediated dilation.

Citation: RCT showing improvement in endothelial function.
Improvement noted in endothelial markers.
Inhibition of SARS-CoV-2 infection
Low
Population: In vitro studies
Study type: Case series
Dose context: 200 mg typical

OPCs showed inhibitory activity against SARS-CoV-2 infection.

Citation: Chen et al. (2023). The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2. eLife.•DOI: 10.7554/eLife.84899
In vitro study showing potential antiviral effects.
Pycnogenol (French Maritime Pine Bark)Moderate
Daily with meals •
Pycnogenol supports vascular health and reduces inflammation.
Buy ingredient →
100mg
Endothelial function improvement
Moderate
Population: Patients with stable coronary artery disease
Study type: RCT
Dose context: 150 mg typical (range: 150–150 mg) • Duration: 10 days

Pycnogenol supplementation improved endothelium-dependent vasodilation.

Citation: Enseleit et al. (2012). Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. Frontiers in Physiology.•DOI: 10.1093/eurheartj/ehr482
Cognitive function improvement
Low
Population: Adults with ADHD
Study type: RCT
Dose context: 100 mg typical

Pycnogenol was compared to methylphenidate and showed potential benefits in improving attention.

Citation: Tenenbaum et al. (2002). An experimental comparison of Pycnogenol and methylphenidate in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Diagnostics.•DOI: 10.1177/108705470200600201
Post-COVID-19 condition symptom relief
Moderate
Population: Individuals with post-COVID-19 condition
Study type: RCT
Dose context: 200 mg typical (range: 200–200 mg) • Duration: 12 weeks

Pycnogenol may alleviate symptoms associated with post-COVID-19 condition.

Citation: Radtke et al. (2024). Effects of Pycnogenol in people with post-COVID-19 condition (PYCNOVID): study protocol for a single-center, placebo controlled, quadruple-blind, randomized trial. Frontiers in Cellular and Infection Microbiology.•DOI: 10.1186/s13063-024-08187-6
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Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Grape Seed Extract (OPCs)
Take ~1h before the intended effect window
Reaches peak plasma concentration in ~1h. Half-life ~5h.
Pycnogenol (French Maritime Pine Bark)
Take ~1h before the intended effect window
Reaches peak plasma concentration in ~1h. Half-life ~3h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

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