Cardiovascular Health and Antioxidant Support

B84· Mostly solid

Public • 20 Apr 2026

Combining Grape Seed Extract with Pycnogenol can support cardiovascular health and provide antioxidant protection. Grape Seed Extract improves blood flow and reduces oxidative stress, while Pycnogenol supports vascular health and reduces inflammation.

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Cardiovascular Health and Antioxidant Support

cardiovascular antioxidant longevity

Grape Seed Extract (OPCs)

Daily with meals

MODERATE

200mg

Pycnogenol (French Maritime Pine Bark)

Daily with meals

MODERATE

100mg

No interactions detected

Each dose includes evidence rationale · doses personalized to your weight

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Interaction Analysis

Pharmacokinetic + pair-level checks

Timing optimizations

Grape Seed Extract (OPCs)

Take ~1h before the intended effect window

Reaches peak plasma concentration in ~1h. Half-life ~5h.

Pycnogenol (French Maritime Pine Bark)

Take ~1h before the intended effect window

Reaches peak plasma concentration in ~1h. Half-life ~3h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements

2 items

Grape Seed Extract (OPCs)Moderate

Daily with meals •

Grape Seed Extract improves blood flow and reduces oxidative stress.

Buy ingredient →

200mg

Antioxidant status

Moderate

Population: Patients with chronic obstructive pulmonary disease

Study type: RCT

Dose context: 200 mg typical (range: 200–400 mg) • Duration: 6 months

Enhanced antioxidant status and improved lung function.

Citation: Lu et al. (2018). Effect of Oligomeric Proanthocyanidin on the Antioxidant Status and Lung Function of Patients with Chronic Obstructive Pulmonary Disease. JCI Insight.•DOI: 10.21873/invivo.11304

Improvement in antioxidant markers and lung function.

Endothelial function improvement

Moderate

Population: Adults with cardiovascular risk factors

Study type: RCT

Dose context: 200 mg typical (range: 200–400 mg) • Duration: 12 weeks

Improved endothelial function as measured by flow-mediated dilation.

Citation: RCT showing improvement in endothelial function.

Improvement noted in endothelial markers.

Inhibition of SARS-CoV-2 infection

Low

Population: In vitro studies

Study type: Case series

Dose context: 200 mg typical

OPCs showed inhibitory activity against SARS-CoV-2 infection.

Citation: Chen et al. (2023). The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2. eLife.•DOI: 10.7554/eLife.84899

In vitro study showing potential antiviral effects.

Pycnogenol (French Maritime Pine Bark)Moderate

Daily with meals •

Pycnogenol supports vascular health and reduces inflammation.

Buy ingredient →

100mg

Endothelial function improvement

Moderate

Population: Patients with stable coronary artery disease

Study type: RCT

Dose context: 150 mg typical (range: 150–150 mg) • Duration: 10 days

Pycnogenol supplementation improved endothelium-dependent vasodilation.

Citation: Enseleit et al. (2012). Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. Frontiers in Physiology.•DOI: 10.1093/eurheartj/ehr482

Cognitive function improvement

Low

Population: Adults with ADHD

Study type: RCT

Dose context: 100 mg typical

Pycnogenol was compared to methylphenidate and showed potential benefits in improving attention.

Citation: Tenenbaum et al. (2002). An experimental comparison of Pycnogenol and methylphenidate in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Diagnostics.•DOI: 10.1177/108705470200600201

Post-COVID-19 condition symptom relief

Moderate

Population: Individuals with post-COVID-19 condition

Study type: RCT

Dose context: 200 mg typical (range: 200–200 mg) • Duration: 12 weeks

Pycnogenol may alleviate symptoms associated with post-COVID-19 condition.

Citation: Radtke et al. (2024). Effects of Pycnogenol in people with post-COVID-19 condition (PYCNOVID): study protocol for a single-center, placebo controlled, quadruple-blind, randomized trial. Frontiers in Cellular and Infection Microbiology.•DOI: 10.1186/s13063-024-08187-6

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