StackTerminal.Health

BETA

Grape Seed Extract (OPCs)

Grape Seed Extract is rich in proanthocyanidins, offering potent antioxidant and anti-inflammatory effects, particularly beneficial for cardiovascular health and blood pressure reduction.

cardiovascularantioxidantblood-pressureanti-inflammatoryskin-health
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
Blood Pressure
Inflammation
Oxidative Stress (MDA)
Evidence
4 records
Blood pressure reduction
Adults with hypertension • Meta-analysis
PUBMEDHigh

Significant reduction in systolic and diastolic blood pressure.

Dose: 200 mgDuration: 8 weeksForm: CapsuleTiming: Daily
Citation: Meta-analysis of multiple RCTs showing blood pressure reduction.
Consistent findings across studies.
Endothelial function improvement
Adults with cardiovascular risk factors • RCT
PUBMEDModerate

Improved endothelial function as measured by flow-mediated dilation.

Dose: 200 mgDuration: 12 weeksForm: CapsuleTiming: Daily
Citation: RCT showing improvement in endothelial function.
Improvement noted in endothelial markers.
Inhibition of SARS-CoV-2 infection
In vitro studies • Case series
PUBMEDLow

OPCs showed inhibitory activity against SARS-CoV-2 infection.

Dose: 200 mg
Citation: Chen et al. (2023). The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2. eLife.
In vitro study showing potential antiviral effects.
Antioxidant status
Patients with chronic obstructive pulmonary disease • RCT
PUBMEDModerate

Enhanced antioxidant status and improved lung function.

Dose: 200 mgDuration: 6 monthsForm: CapsuleTiming: Daily
Citation: Lu et al. (2018). Effect of Oligomeric Proanthocyanidin on the Antioxidant Status and Lung Function of Patients with Chronic Obstructive Pulmonary Disease. JCI Insight.
Improvement in antioxidant markers and lung function.
Forms
Capsule
Standardized to contain a specific percentage of OPCs for consistent dosing.
Powder
Can be mixed with liquids or foods, often used for higher doses.
Liquid Extract
Concentrated form, typically used in smaller doses.

Stacks containing Grape Seed Extract (OPCs)

Public community stacks that include this ingredient.

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cardiovascularantioxidantlongevity

Cardiovascular Health and Antioxidant Support

by@athlete

Combining Grape Seed Extract with Pycnogenol can support cardiovascular health and provide antioxidant protection. Grape Seed Extract improves blood flow and reduces oxidative stress, while Pycnogenol supports vascular health and reduces inflammation.

Grape Seed Extract (OPCs)
200mg
Pycnogenol (French Maritime Pine Bark)
100mg
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