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Pycnogenol (French Maritime Pine Bark)

Pycnogenol is a standardized pine bark extract rich in procyanidins, known for improving endothelial function, reducing symptoms of chronic venous insufficiency, decreasing osteoarthritis pain, and enhancing attention in ADHD. It has anti-inflammatory, antioxidant, and vascular benefits.

cardiovascularantioxidantjoint healthanti inflammatorycognitive

Evidence last reviewed: 20 Apr 2026

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Evidence
5 records
5 recordsBest grade:Moderate
Biomarkers
Blood PressureFocus / AttentionIL-6CRP (Inflammation)Immune Function

The evidence for Pycnogenol includes moderate support for improving endothelial function and reducing inflammation, particularly in specific populations. However, many studies have low sample sizes and varying methodologies, indicating a need for more robust research.

Inflammatory biomarkers reduction
Adults with gingival inflammation · RCT
Moderate

Pycnogenol supplementation reduced inflammatory biomarkers in saliva and serum.

Dose: 200 mgDuration: 3 months
Citation: Bayer et al. (2025). Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy-A Randomized Placebo-Controlled Double-Blind Trial. Nutrients.
Skin health improvement
Women with melasma · RCT
Low

Pycnogenol showed efficacy in improving skin health and reducing hyperpigmentation.

Dose: 100 mgDuration: 30 days
Citation: Ni et al. (2002). Treatment of melasma with Pycnogenol. Frontiers in Immunology.
Endothelial function improvement
Patients with stable coronary artery disease · RCT
Moderate

Pycnogenol supplementation improved endothelium-dependent vasodilation.

Dose: 150 mgDuration: 10 days
Citation: Enseleit et al. (2012). Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. Frontiers in Physiology.
Cognitive function improvement
Adults with ADHD · RCT
Low

Pycnogenol was compared to methylphenidate and showed potential benefits in improving attention.

Dose: 100 mg
Citation: Tenenbaum et al. (2002). An experimental comparison of Pycnogenol and methylphenidate in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Diagnostics.
Post-COVID-19 condition symptom relief
Individuals with post-COVID-19 condition · RCT
Moderate

Pycnogenol may alleviate symptoms associated with post-COVID-19 condition.

Dose: 200 mgDuration: 12 weeks
Citation: Radtke et al. (2024). Effects of Pycnogenol in people with post-COVID-19 condition (PYCNOVID): study protocol for a single-center, placebo controlled, quadruple-blind, randomized trial. Frontiers in Cellular and Infection Microbiology.
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Cardiovascular Health and Antioxidant Support

by@athlete

Combining Grape Seed Extract with Pycnogenol can support cardiovascular health and provide antioxidant protection. Grape Seed Extract improves blood flow and reduces oxidative stress, while Pycnogenol supports vascular health and reduces inflammation.

Grape Seed Extract (OPCs)
200mg
Pycnogenol (French Maritime Pine Bark)
100mg
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Forms & usage▾
How to take it

Take 50-100 mg daily, preferably with meals.

Capsule
Commonly used form for oral supplementation.
Tablet
Another popular form for ease of use.
Powder
Can be mixed with liquids for those who prefer not to take pills.
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