Grape Seed Extract (OPCs)
Grape Seed Extract is rich in proanthocyanidins, offering potent antioxidant and anti-inflammatory effects, particularly beneficial for cardiovascular health and blood pressure reduction.
Evidence last reviewed: 20 Apr 2026
The evidence supports Grape Seed Extract's role in improving endothelial function and lowering blood pressure, with moderate to high quality studies backing these claims. However, more research is needed on its effects in diverse populations and long-term use.
Blood pressure reductionAdults with hypertension · Meta-analysisHigh
Significant reduction in systolic and diastolic blood pressure.
Endothelial function improvementAdults with cardiovascular risk factors · RCTModerate
Improved endothelial function as measured by flow-mediated dilation.
Inhibition of SARS-CoV-2 infectionIn vitro studies · Case seriesLow
OPCs showed inhibitory activity against SARS-CoV-2 infection.
Antioxidant statusPatients with chronic obstructive pulmonary disease · RCTModerate
Enhanced antioxidant status and improved lung function.
Combining Grape Seed Extract with Pycnogenol can support cardiovascular health and provide antioxidant protection. Grape Seed Extract improves blood flow and reduces oxidative stress, while Pycnogenol supports vascular health and reduces inflammation.
Forms & usage▾
Take 100-300 mg daily, preferably with meals.