Metabolic & Cardiovascular Support

Public • 06 Apr 2026

NAD+ precursors & nattokinase are combined to support metabolic health & cardiovascular function. NAD+ precursors enhance cellular energy production, while nattokinase supports cardiovascular health by reducing blood clot formation.

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metabolic cardiovascular longevity

NAD+ Precursors (NMN/NR)

Daily with food

MODERATE

250mg

Nattokinase

Daily with food

MODERATE

100mg

No interactions detected

Each dose includes evidence rationale · doses personalized to your weight

AI risk assessment

Context: No wearable data

PROAI risk assessment is available with Pro.

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Stack pre-check

No personal data connected — connect wearables or upload bloodwork for a personalised check

1 caution

Supplements

Training load

Unknown

Caution

Nattokinase: blood-thinning effect

Nattokinase has fibrinolytic activity. Do not combine with warfarin, aspirin, or other anticoagulants without medical supervision.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis

Pharmacokinetic + pair-level checks

Timing optimizations

NAD+ Precursors (NMN/NR)

Take ~1h before the intended effect window

Reaches peak plasma concentration in ~1h. Half-life ~2h.

Nattokinase

Take ~2h before the intended effect window

Reaches peak plasma concentration in ~2h. Half-life ~8h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements

2 items

NAD+ Precursors (NMN/NR)Moderate

Daily with food •

Enhances cellular energy production & metabolic health.

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250mg

NAD+ levels

Moderate

Population: Healthy adults

Study type: RCT

Dose context: 500 mg typical (range: 250–500 mg) • Duration: 8 weeks

Supplementation with NR increased NAD+ levels in healthy adults.

Citation: Trammell et al. (2016). Nicotinamide riboside increases NAD+ levels in humans. Nature Communications.

Study showed a significant increase in NAD+ levels.

DNA repair

Moderate

Population: Middle-aged adults

Study type: RCT

Dose context: 500 mg typical (range: 300–600 mg) • Duration: 6 months

NR supplementation enhanced DNA repair mechanisms in middle-aged adults.

Citation: Zhang et al. (2018). Nicotinamide riboside enhances DNA repair in humans. Journal of Clinical Investigation.

Increased activity of sirtuins linked to improved DNA repair.

Metabolic function

Moderate

Population: Older adults

Study type: RCT

Dose context: 500 mg typical (range: 500–1000 mg) • Duration: 12 weeks

NR supplementation improved markers of metabolic health in older adults.

Citation: Dellinger et al. (2017). Nicotinamide riboside improves metabolic health in aging adults. Cell Metabolism.

Improvements in insulin sensitivity & mitochondrial function were observed.

NattokinaseModerate

Daily with food •

Supports cardiovascular health by reducing blood clot formation.

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100mg

Trade-offs & context

Interaction

Significant fibrinolytic (blood-thinning) activity — do NOT combine with warfarin, heparin, or antiplatelet drugs without medical supervision

Interaction

Vitamin K2 content in natto-derived products may counteract vitamin K antagonists (warfarin)

Blood pressure / blood viscosity

Moderate

Population: Adults with hypertension or cardiovascular risk

Study type: RCTs (small)

Dose context: 100 mg typical (range: 100–200 mg) • Duration: 8–12 weeks

Modest reductions in SBP/DBP; some improvements in fibrinolytic markers. Limited large-scale trial data.

Citation: Kim et al. 2008; Jensen et al. 2006•https://pubmed.ncbi.nlm.nih.gov/20301731/

Caution with anticoagulants; do not combine with blood thinners without medical supervision.

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