StackTerminal.Health

BETA

Metabolic Health & Weight Management

Public • 06 Apr 2026

Metformin & intermittent fasting are combined to support metabolic health & weight management. Metformin improves insulin sensitivity & glucose metabolism, while intermittent fasting aids in weight management & metabolic regulation.

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Metabolic Health & Weight Management
metabolicweight-managementblood-sugar
Metformin
With meals
MODERATE
500mg
Intermittent Fasting
Daily
MODERATE
0mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
AI risk assessment
Context: No wearable data
PROAI risk assessment is available with Pro.
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Stack pre-check
No personal data connected — connect wearables or upload bloodwork for a personalised check
Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Metformin
Take ~2.5h before the intended effect window
Reaches peak plasma concentration in ~2.5h. Half-life ~6.2h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
MetforminModerate
With meals •
Improves insulin sensitivity & glucose metabolism.
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500mg
All-cause mortality
Moderate
Population: Patients with type 2 diabetes
Study type: Systematic review
Dose context: 1500 mg typical

Metformin reduces all-cause mortality & diseases of aging independent of its effect on diabetes control.

Citation: Campbell et al. (2017). Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis. Journal of Endocrinological Investigation.•DOI: 10.1007/s40618-021-01691-5
Insulin sensitivity
Moderate
Population: Women with polycystic ovary syndrome (PCOS)
Study type: Systematic review
Dose context: 1500 mg typical

Metformin is widely used to treat insulin resistance in PCOS, although it may cause gastrointestinal side effects.

Citation: Greff et al. (2023). Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reproductive Biology and Endocrinology.•DOI: 10.1186/s12958-023-01055-z
Weight management
Moderate
Population: Patients with obesity
Study type: Systematic review
Dose context: 1500 mg typical

Metformin has been shown to aid in weight management in patients with obesity.

Citation: Masarwa et al. (2021). Efficacy and Safety of Metformin for Obesity: A Systematic Review. International Journal of Molecular Sciences.•DOI: 10.3390/ijms23084110
Intermittent FastingHigh
Daily •
Aids in weight management & metabolic regulation.
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0mg
Metabolic health
High
Population: General adult population
Study type: Umbrella review
Dose context: —

Intermittent fasting improved metabolic health markers compared to ad-libitum diets.

Citation: Patikorn et al. (2021). Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials.•DOI: 10.1155/2013/210524
Glycemic control
Moderate
Population: Adults with diabetes
Study type: RCT
Dose context: —

A 5:2 intermittent fasting meal replacement diet improved glycemic control & reduced body weight.

Citation: Guo et al. (2024). A 5:2 Intermittent Fasting Meal Replacement Diet and Glycemic Control for Adults With Diabetes: The EARLY Randomized Clinical Trial.•DOI: 10.1017/S0029665116002986
Cardiometabolic risk factors
High
Population: General adult population
Study type: Systematic review
Dose context: —

Intermittent fasting diets showed similar benefits to continuous energy restriction for weight loss & cardiometabolic risk factors.

Citation: Dong et al. (2020). Intermittent Fasting: A Heart Healthy Dietary Pattern?•DOI: 10.1016/j.clnu.2017.11.018
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