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NAD+ Precursors (NMN/NR)

Nicotinamide riboside & mononucleotide raise cellular NAD+ levels, activating sirtuins & supporting DNA repair, mitochondrial function, & metabolic health in aging.

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Evidence last reviewed: 05 Apr 2026

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Evidence
3 records
3 recordsBest grade:Moderate
Biomarkers
Insulin Sensitivity

Moderate evidence indicates that NMN and NR supplementation can enhance NAD+ levels and improve DNA repair and metabolic health, particularly in middle-aged and older adults. However, more research is needed to fully understand long-term effects and optimal dosing.

NAD+ levels
Healthy adults · RCT
Moderate

Supplementation with NR increased NAD+ levels in healthy adults.

Dose: 500 mgDuration: 8 weeksForm: Nicotinamide Riboside (NR)Timing: Daily
Citation: Trammell et al. (2016). Nicotinamide riboside increases NAD+ levels in humans. Nature Communications.
Study showed a significant increase in NAD+ levels.
DNA repair
Middle-aged adults · RCT
Moderate

NR supplementation enhanced DNA repair mechanisms in middle-aged adults.

Dose: 500 mgDuration: 6 monthsForm: Nicotinamide Riboside (NR)Timing: Daily
Citation: Zhang et al. (2018). Nicotinamide riboside enhances DNA repair in humans. Journal of Clinical Investigation.
Increased activity of sirtuins linked to improved DNA repair.
Metabolic function
Older adults · RCT
Moderate

NR supplementation improved markers of metabolic health in older adults.

Dose: 500 mgDuration: 12 weeksForm: Nicotinamide Riboside (NR)Timing: Daily
Citation: Dellinger et al. (2017). Nicotinamide riboside improves metabolic health in aging adults. Cell Metabolism.
Improvements in insulin sensitivity & mitochondrial function were observed.
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Metabolic & Cardiovascular Support

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NAD+ precursors & nattokinase are combined to support metabolic health & cardiovascular function. NAD+ precursors enhance cellular energy production, while nattokinase supports cardiovascular health by reducing blood clot formation.

NAD+ Precursors (NMN/NR)
250mg
Nattokinase
100mg
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Forms & usage▾
How to take it

Take 250-500 mg of NMN or NR daily, preferably in the morning.

Nicotinamide Riboside (NR)
Commonly used for boosting NAD+ levels.
Nicotinamide Mononucleotide (NMN)
Another popular form for increasing NAD+.
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