Current evidence suggests nattokinase may lead to modest reductions in blood pressure and improvements in blood viscosity markers, but the studies are small and lack large-scale trials. More research is needed to confirm these benefits and establish optimal dosing.
Blood pressure / blood viscosityAdults with hypertension or cardiovascular risk · RCTs (small)Moderate
Modest reductions in SBP/DBP; some improvements in fibrinolytic markers. Limited large-scale trial data.
Metabolic & Cardiovascular Support
NAD+ precursors & nattokinase are combined to support metabolic health & cardiovascular function. NAD+ precursors enhance cellular energy production, while nattokinase supports cardiovascular health by reducing blood clot formation.
Forms & usage▾
Take 100-200 mg daily, preferably on an empty stomach.
Safety & trade-offs2▾
Significant fibrinolytic (blood-thinning) activity — do NOT combine with warfarin, heparin, or antiplatelet drugs without medical supervision
Vitamin K2 content in natto-derived products may counteract vitamin K antagonists (warfarin)
●High ●Moderate ● Low / note