StackTerminal.Health

BETA

Vitamin D3

Fat-soluble vitamin with broad roles in immune function, bone health, & musculoskeletal performance.

longevityimmune
Evidence last reviewed: 04 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Performance
Muscle Strength (1RM)Power OutputMuscle Endurance
Bloodwork
Vitamin D (25-OH)
Evidence
3 records
Prevention of acute respiratory tract infections
Children and adults (ages 0–95); 25 RCTs, n=11,321Systematic review and meta-analysis of individual participant data from RCTs
PUBMEDModerate

Vitamin D supplementation reduced risk of acute respiratory tract infection (adjusted OR 0.88, 95% CI 0.81–0.96); greatest benefit in those with baseline deficiency (<25 nmol/L) & those receiving daily or weekly dosing rather than bolus doses.

Dose:
IPD meta-analysis; high statistical power; effect strongest in vitamin D-deficient individuals.
Vitamin D status & physical performance in athletes
Competitive and recreational athletesNarrative review
PUBMEDLow

Vitamin D insufficiency is prevalent among athletes, particularly indoor athletes & those in northern latitudes in winter. Insufficiency is associated with reduced muscle strength, power, & endurance; supplementation of 2,000–6,000 IU/day recommended to maintain 25(OH)D >40 ng/mL.

Dose:
Narrative review; prevalence data robust, intervention evidence more limited.
Fracture prevention in elderly adults
Ambulatory and institutionalized elderly personsSystematic review and meta-analysis of RCTs
PUBMEDModerate

Vitamin D at 700–800 IU/day reduced hip fracture risk by 26% (RR 0.74) & any nonvertebral fracture by 23% (RR 0.77); no significant benefit was observed at 400 IU/day.

Dose:
Dose-dependent effect; 400 IU/day insufficient for fracture prevention.
Forms
Cholecalciferol
Preferred over D2

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