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Sleep Quality and Relaxation

Combining Tryptophan with Passionflower can enhance sleep quality and promote relaxation. Tryptophan is a precursor to serotonin and melatonin, supporting sleep, while Passionflower is known for its calming effects.

What this is for
General support
sleep, relaxation, calm
Why you are seeing this
Goal fit: sleep, relaxation, calm.
What to do next
Add body metrics if you want dose previews to reflect your weight rather than the reference dose.
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Buy stack
Public•Built 20 Apr 2026•2 ingredients•No interactions detected
Core stack
The main ingredients doing the work.
2 key items
L-TryptophanModerate
Before bed •
Tryptophan is a precursor to serotonin and melatonin, supporting sleep.
Buy ingredient →
1000mg
sleep quality
Moderate
Population: general population
Study type: Systematic review
Dose context: 2000 mg typical (range: 1000–? mg)

L-Tryptophan supplementation was found to aid in improving sleep quality.

Citation: Sutanto et al. (2022). The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutrition Reviews.•DOI: 10.1093/nutrit/nuab027
mood improvement
Moderate
Population: healthy adults
Study type: Systematic review
Dose context: 2000 mg typical

Tryptophan intake may decrease anxiety and increase positive mood in healthy individuals.

Citation: Qureshi et al. (2021). Nutritional supplementation in the treatment of violent and aggressive behavior: A systematic review. Aggression and Violent Behavior.•DOI: 10.1002/ab.21953
wake after sleep onset
Moderate
Population: individuals with insomnia
Study type: Systematic review
Dose context: 2000 mg typical (range: 1000–? mg)

Tryptophan supplementation significantly shortened wake after sleep onset.

Citation: Sarris et al. (2011). A systematic review of insomnia and complementary medicine. Sleep Medicine Reviews.•DOI: 10.1016/j.smrv.2010.04.001
PassionflowerModerate
Before bed •
Passionflower is known for its calming effects.
Buy ingredient →
500mg
Anxiety reduction
Moderate
Population: Adults with anxiety disorders
Study type: Systematic review
Dose context: 500 mg typical

Passionflower preparations were found to reduce anxiety levels, with effects less evident in mild anxiety.

Citation: Zhang et al. (2022). Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Journal of Ethnopharmacology.•DOI: 10.1016/j.jep.2004.02.023
Anxiety reduction
Moderate
Population: Generalized anxiety disorder patients
Study type: RCT
Dose context: 500 mg typical

Passionflower extract was comparable to oxazepam in reducing anxiety symptoms.

Citation: Akhondzadeh et al. (2001). Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.•DOI: 10.1046/j.1365-2710.2001.00367.x
Opioid withdrawal symptom reduction
Low
Population: Patients undergoing opioid withdrawal
Study type: Systematic review
Dose context: 500 mg typical

Passionflower may aid in reducing symptoms of opioid withdrawal.

Citation: Kruszecki et al. (2021). A systematic review of integrative medicine for opioid withdrawal.•DOI: 10.4097/kjae.2016.69.4.319
Stack pre-check
No personal data connected — connect wearables or upload bloodwork for a personalised check
Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
L-Tryptophan
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~1.5h.
Passionflower
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~1h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

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