StackTerminal.Health

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Sleep Quality and Relaxation

B84· Mostly solid
Public 20 Apr 2026

Combining Tryptophan with Passionflower can enhance sleep quality and promote relaxation. Tryptophan is a precursor to serotonin and melatonin, supporting sleep, while Passionflower is known for its calming effects.

Sleep Quality and Relaxation
L-Tryptophan
Before bed
MODERATE
1000mg
Passionflower
Before bed
MODERATE
500mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
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Stack pre-check
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Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
L-Tryptophan
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~1.5h.
Passionflower
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~1h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
L-TryptophanModerate
Before bed
Tryptophan is a precursor to serotonin and melatonin, supporting sleep.
1000mg
sleep quality
Moderate
Population: general population
Study type: Systematic review
Dose context: 2000 mg typical (range: 1000–? mg)

L-Tryptophan supplementation was found to aid in improving sleep quality.

Citation: Sutanto et al. (2022). The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutrition Reviews.DOI: 10.1093/nutrit/nuab027
mood improvement
Moderate
Population: healthy adults
Study type: Systematic review
Dose context: 2000 mg typical

Tryptophan intake may decrease anxiety and increase positive mood in healthy individuals.

Citation: Qureshi et al. (2021). Nutritional supplementation in the treatment of violent and aggressive behavior: A systematic review. Aggression and Violent Behavior.DOI: 10.1002/ab.21953
wake after sleep onset
Moderate
Population: individuals with insomnia
Study type: Systematic review
Dose context: 2000 mg typical (range: 1000–? mg)

Tryptophan supplementation significantly shortened wake after sleep onset.

Citation: Sarris et al. (2011). A systematic review of insomnia and complementary medicine. Sleep Medicine Reviews.DOI: 10.1016/j.smrv.2010.04.001
Before bed
Passionflower is known for its calming effects.
500mg
Anxiety reduction
Moderate
Population: Adults with anxiety disorders
Study type: Systematic review
Dose context: 500 mg typical

Passionflower preparations were found to reduce anxiety levels, with effects less evident in mild anxiety.

Citation: Zhang et al. (2022). Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Journal of Ethnopharmacology.DOI: 10.1016/j.jep.2004.02.023
Anxiety reduction
Moderate
Population: Generalized anxiety disorder patients
Study type: RCT
Dose context: 500 mg typical

Passionflower extract was comparable to oxazepam in reducing anxiety symptoms.

Citation: Akhondzadeh et al. (2001). Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.DOI: 10.1046/j.1365-2710.2001.00367.x
Opioid withdrawal symptom reduction
Low
Population: Patients undergoing opioid withdrawal
Study type: Systematic review
Dose context: 500 mg typical

Passionflower may aid in reducing symptoms of opioid withdrawal.

Citation: Kruszecki et al. (2021). A systematic review of integrative medicine for opioid withdrawal.DOI: 10.4097/kjae.2016.69.4.319

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