StackTerminal.Health

BETA

L-Tryptophan

L-Tryptophan is an essential amino acid that serves as a direct precursor to serotonin, supporting mood and sleep improvement. It is often used for mood support, sleep enhancement, and managing symptoms of PMS and seasonal affective disorder.

sleepmooddepressionanxietynutritional
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Sleep
Sleep Quality (subjective)
Cognitive
Mood / WellbeingAnxiety
Gut
Gut Microbiome
Evidence
4 records
sleep quality
general populationSystematic review
PUBMEDModerate

L-Tryptophan supplementation was found to aid in improving sleep quality.

Dose: 2000 mg
mood improvement
healthy adultsSystematic review
PUBMEDModerate

Tryptophan intake may decrease anxiety and increase positive mood in healthy individuals.

Dose: 2000 mg
wake after sleep onset
individuals with insomniaSystematic review
PUBMEDModerate

Tryptophan supplementation significantly shortened wake after sleep onset.

Dose: 2000 mg
gut microbiota modulation
healthy subjectsRCT
PUBMEDLow

Oral tryptophan activated duodenal aryl hydrocarbon receptor, influencing gut microbiota.

Dose: 2000 mgDuration: 4 weeks
Forms
Capsule
Commonly used for ease of dosing.
Powder
Can be mixed with liquids for flexible dosing.

Stacks containing L-Tryptophan

Public community stacks that include this ingredient.

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sleeprelaxationcalm

Combining Tryptophan with Passionflower can enhance sleep quality and promote relaxation. Tryptophan is a precursor to serotonin and melatonin, supporting sleep, while Passionflower is known for its calming effects.

L-Tryptophan
1000mg
Passionflower
500mg
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