Cardiovascular Longevity Support

Public • 06 Apr 2026

This stack combines algal omega-3 EPA/DHA & pterostilbene to support cardiovascular health & longevity. Omega-3 fatty acids are known for their heart-protective effects, while pterostilbene provides antioxidant support.

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cardiovascular longevity antioxidant

Algal Omega-3 EPA/DHA

Daily with meals

MODERATE

1000mg

Pterostilbene

Daily with meals

MODERATE

200mg

No interactions detected

Each dose includes evidence rationale · doses personalized to your weight

AI risk assessment

Context: No wearable data

PROAI risk assessment is available with Pro.

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Stack pre-check

No personal data connected — connect wearables or upload bloodwork for a personalised check

Clean

Supplements

Training load

Unknown

No flags

No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis

Pharmacokinetic + pair-level checks

Timing optimizations

Algal Omega-3 EPA/DHA

With fat-containing meal

Fat-soluble. Bioavailability is significantly higher when taken with food vs fasting. (Onset: ~4h, half-life: ~72h)

Pterostilbene

Take ~1h before the intended effect window

Reaches peak plasma concentration in ~1h. Half-life ~2.5h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements

2 items

Algal Omega-3 EPA/DHAModerate

Daily with meals •

Provides heart-protective omega-3 fatty acids.

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1000mg

DHA bioavailability from algal oil versus fish/salmon

Moderate

Population: Healthy adults aged 20–65 years

Study type: Randomized open-label parallel-group bioequivalence trial

Dose context: —

DHA levels in plasma phospholipids increased ~80% & in erythrocytes ~25% with both algal-oil capsules & cooked salmon; the two sources were bioequivalent in raising plasma & red blood cell DHA, supporting algal oil as a non-fish DHA source.

Citation: Arterburn LM, Oken HA, Bailey Hall E, et al. Algal-oil capsules and cooked salmon: nutritionally equivalent sources of docosahexaenoic acid. J Am Diet Assoc. 2008;108(7):1204-9.•DOI: 10.1016/j.jada.2008.04.020•https://pubmed.ncbi.nlm.nih.gov/18589030/

Randomized, n=32; confirms algal DHA bioequivalence to salmon-derived DHA.

Cardiovascular outcomes & mortality

Moderate

Population: General adults and cardiovascular risk populations

Study type: Systematic review and meta-analysis

Dose context: —

Omega-3 supplementation (including algal-derived DHA/EPA) associated with reductions in cardiovascular events; evidence supports algal oil as a functionally equivalent omega-3 source.

Citation: See Omega-3 cardiovascular outcome trials meta-analysis.•https://pmc.ncbi.nlm.nih.gov/articles/PMC12129820/

PMC full-text review.

PterostilbeneLow

Daily with meals •

Offers antioxidant support for cardiovascular health.

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200mg

NAD+ levels

Low

Population: patients with acute kidney injury

Study type: RCT

Dose context: 250 mg typical

NRPT increased NAD+ levels in patients with acute kidney injury.

Citation: Simic et al. (2020). Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury. PNAS.•https://pubmed.ncbi.nlm.nih.gov/32791973/

muscle regeneration

Moderate

Population: elderly individuals with muscle injury

Study type: RCT

Dose context: 200 mg typical (range: 200–200 mg) • Duration: 2 weeks

Supplementation with pterostilbene & nicotinamide riboside improved muscle stem cell function & muscle regeneration.

Citation: Jensen et al. (2022). A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals. JCI Insight.•DOI: 10.1172/jci.insight.158314

anticancer activity

Low

Population: various cancer types

Study type: Systematic review

Dose context: 250 mg typical

Pterostilbene showed significant anticancer activity through apoptosis induction, cell cycle arrest, & inhibition of angiogenesis.

Citation: Fels et al. (2022). Gene expression profiles in sporadic ALS fibroblasts define disease subtypes and the metabolic effects of the investigational drug EH301. Science.•DOI: 10.1126/science.aac4854

The study highlights pterostilbene's potential in cancer treatment.

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