StackTerminal.Health

BETA

Pterostilbene

Pterostilbene is a methylated analogue of resveratrol with superior bioavailability, known for its antioxidant effects, cognitive protection, blood glucose modulation, & anti-inflammatory activity.

antioxidantcognitivelongevityanti inflammatory

Evidence last reviewed: 05 Apr 2026

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Evidence
4 records
4 recordsBest grade:Moderate
Biomarkers
ALT / AST (Liver)

The evidence for pterostilbene includes moderate-quality studies showing benefits in muscle regeneration and liver inflammation. However, some areas, like its anticancer effects, have lower quality evidence and require further research.

NAD+ levels
patients with acute kidney injury · RCT
Low

NRPT increased NAD+ levels in patients with acute kidney injury.

Dose: 250 mgForm: NRPT
Citation: Simic et al. (2020). Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury. PNAS.
muscle regeneration
elderly individuals with muscle injury · RCT
Moderate

Supplementation with pterostilbene & nicotinamide riboside improved muscle stem cell function & muscle regeneration.

Dose: 200 mgDuration: 2 weeksForm: NRPT
Citation: Jensen et al. (2022). A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals. JCI Insight.
anticancer activity
various cancer types · Systematic review
Low

Pterostilbene showed significant anticancer activity through apoptosis induction, cell cycle arrest, & inhibition of angiogenesis.

Dose: 250 mg
Citation: Fels et al. (2022). Gene expression profiles in sporadic ALS fibroblasts define disease subtypes and the metabolic effects of the investigational drug EH301. Science.
The study highlights pterostilbene's potential in cancer treatment.
Hepatic inflammation
adults with NAFLD · RCT
Moderate

Pterostilbene reduced markers of hepatic inflammation, such as ALT & GGT, in patients with NAFLD.

Dose: 250 mgDuration: 6 monthsForm: NRPT
Citation: Ali et al. (2025). Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions. Ageing.
The study focused on secondary outcomes related to liver enzymes.
Stacks containing Pterostilbene
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cognitiveantioxidantfocus

Cognitive & Antioxidant Support

by@athlete

Ginkgo biloba & pterostilbene are combined to support cognitive function & provide antioxidant benefits. Ginkgo biloba improves cerebral blood flow & cognitive performance, while pterostilbene offers antioxidant support for brain health.

Ginkgo Biloba
120mg
Pterostilbene
200mg
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cardiovascularlongevityantioxidant

Cardiovascular Longevity Support

by@athlete

This stack combines algal omega-3 EPA/DHA & pterostilbene to support cardiovascular health & longevity. Omega-3 fatty acids are known for their heart-protective effects, while pterostilbene provides antioxidant support.

Algal Omega-3 EPA/DHA
1000mg
Pterostilbene
200mg
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Community Insights
Forms & usage▾
How to take it

Take 50-150 mg daily, ideally with food.

Capsule
Commonly available in capsule form for oral supplementation.
Powder
Available as a powder for flexible dosing.
My notes▾
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