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Creatine Monohydrate

Supports high-intensity performance & lean mass; among the best-studied sports supplements.

focusendurancefatigueperformancepowerrecoverystrength

Evidence last reviewed: 20 Apr 2026

Evidence
2 records
2 recordsBest grade:High
Biomarkers
MemoryCognitive FunctionMuscle Strength (1RM)Power Output

Creatine monohydrate is backed by strong evidence showing improvements in strength, power, and training volume. While it may also enhance cognitive function in some individuals, about 25-30% of users may not respond effectively.

Short-term memory & reasoning
Healthy adults (6 RCTs, n=281); larger effects in older adults · Systematic review of RCTs
Moderate

Oral creatine may improve short-term memory & intelligence/reasoning in healthy individuals; effect on other cognitive domains unclear.

Dose: 5000 mgDuration: 4–12 weeks
Cognitive benefits most consistent in aging or sleep-deprived populations & those with lower dietary creatine (e.g., vegetarians).
Strength / power performance
Healthy adults; athletes and recreationally trained · ISSN Position Stand (comprehensive review)
High

Consistent improvements in strength, power, & training volume; safe for long-term use (up to 30 g/day for 5 years studied). Loading optional; maintenance commonly 3–5 g/day.

Dose: 5000 mgDuration: 4–12+ weeks
Non-responders (~25–30%) exist; vegetarians/vegans tend to show larger gains.
Stacks containing Creatine Monohydrate
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endurancestrengthmens-health

This tailored supplement stack is optimized for enhancing strength, recovery, and overall men's health during your high training load phase. By combining electrolytes for hydration, fish oil for joint support, creatine for muscle power, and HMB for recovery, you'll maximize performance and maintain your edge in strength and power-focused training.

Electrolytes (Sodium / Potassium / Magnesium blend)
1000mg
Fish Oil
2000mg
Creatine Monohydrate
5000mg
New
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endurancestrengthdaily

Year-round base stack to support training output & hydration.

Creatine Monohydrate
5000mg
Sodium Citrate
500mg
New
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longevityanti-agingcellular-health

Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.

Creatine Monohydrate
2500mg
Calcium Alpha-Ketoglutarate (CaAKG)
2000mg
Taurine
1500mg
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strengthconstraints

Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.

Beta-Alanine
4800mg
Creatine Monohydrate
5000mg
HMB (Beta-Hydroxy Beta-Methylbutyrate)
3000mg
New
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strength

High-evidence strength support without grey-area ingredients.

Creatine Monohydrate
5000mg
New
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strength

Supports training without grey-area or banned ingredients.

Creatine Monohydrate
5000mg
Beta-Alanine
3200mg
Magnesium (Glycinate)
400mg
New
View
strength

High-ROI strength support with minimal ingredients.

Creatine Monohydrate
5000mg
New
View
endurance

Based on your goals & preferences, here is a starting stack you can edit.

Vitamin D3
25mg
Magnesium Citrate
1000mg
Caffeine
200mg
New
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recoverysleep

Built from your goals & the supplement evidence library. You can edit doses & timing.

Caffeine
200mg
Beta-Alanine
3200mg
Vitamin D3
50mg
New
View
endurancemens-healthconstraints

This personalized supplement stack is optimized for enhancing your baseline health, supporting recovery, and boosting strength during your active training phase. With Vitamin D3 for immune support, electrolytes for hydration, fish oil for overall wellness, creatine for power, and tart cherry for recovery, this budget-friendly combination will help you maintain peak performance and promote effective recovery.

Vitamin D3
1000mg
Electrolytes (Sodium / Potassium / Magnesium blend)
1000mg
Fish Oil
2000mg
New
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Community Insights
Forms & usage
How to take it

Take 3–5 grams daily, ideally post-workout or spread throughout the day to minimize gastrointestinal discomfort.

Creatine monohydrate
Most studied; good value; stable.
Safety & trade-offs3
Tolerance

Water retention of 1–2 kg in the first week (intramuscular, not fat)

Tolerance

GI discomfort — bloating and cramping; spread loading doses across the day

Context: loading phase >10g/day

Note

Non-responders (~25–30%) see minimal benefit regardless of dose

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