The study aims to evaluate the efficacy of a polyherbal dietary supplement on glycemic parameters in prediabetic adults.

Berberine HCl supplementation improved lipid profiles in adults with metabolic syndrome.

Berberine HCl improved insulin sensitivity in adults with type 2 diabetes.

Berberine reduced LDL cholesterol by 0.46 mmol/L, triglycerides by 0.34 mmol/L, & total cholesterol by 0.48 mmol/L across 18 RCTs; HDL changes differed by sex (increase in women, slight decrease in men). No serious adverse events reported.

Berberine reduced fasting plasma glucose by 0.82 mmol/L, HbA1c by 0.63%, & 2-hour postprandial glucose by 1.16 mmol/L across 37 RCTs (n=3048); glucose-lowering effect correlated with baseline glucose levels.