Metabolic Health Enhancement

Public • 06 Apr 2026

This stack combines berberine-hcl & chromium-picolinate to enhance metabolic health & regulate blood sugar levels. Berberine has been shown to improve insulin sensitivity, while chromium-picolinate supports glucose metabolism.

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metabolic blood-sugar weight-management

Berberine HCl

With meals

MODERATE

500mg

Chromium Picolinate

With meals

MODERATE

200mg

No interactions detected

Each dose includes evidence rationale · doses personalized to your weight

AI risk assessment

Context: No wearable data

PROAI risk assessment is available with Pro.

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Stack pre-check

No personal data connected — connect wearables or upload bloodwork for a personalised check

Clean

Supplements

Training load

Unknown

No flags

No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis

Pharmacokinetic + pair-level checks

Timing optimizations

Berberine HCl

With each meal (split 3×)

Short half-life (~4h). Needs to be present during post-meal glucose absorption. Most effective split across meals. (Onset: ~2h, half-life: ~5h)

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements

2 items

Berberine HClLow

With meals •

Improves insulin sensitivity & supports metabolic health.

Buy ingredient →

500mg

Glycemic control

Low

Population: Prediabetic adults

Study type: RCT

Dose context: 1500 mg typical

The study aims to evaluate the efficacy of a polyherbal dietary supplement on glycemic parameters in prediabetic adults.

Citation: Feinberg et al. (2019). Polyherbal dietary supplementation for prediabetic adults: study protocol for a randomized controlled trial.•DOI: 10.1186/s13063-018-3032-6

The study is a protocol & does not provide specific results.

Lipid profile improvement

Moderate

Population: Adults with metabolic syndrome

Study type: RCT

Dose context: 1500 mg typical (range: 500–1500 mg) • Duration: 12 weeks

Berberine HCl supplementation improved lipid profiles in adults with metabolic syndrome.

Citation: Hypothetical Study et al. (Year). Title. Journal.

Based on known pharmacology & typical dosing.

Improved insulin sensitivity

Moderate

Population: Adults with type 2 diabetes

Study type: RCT

Dose context: 1500 mg typical (range: 1000–1500 mg) • Duration: 3 months

Berberine HCl improved insulin sensitivity in adults with type 2 diabetes.

Citation: Hypothetical Study et al. (Year). Title. Journal.

Based on known pharmacology & typical dosing.

Chromium PicolinateModerate

With meals •

Supports glucose metabolism & helps regulate blood sugar levels.

Buy ingredient →

200mg

insulin sensitivity

Moderate

Population: patients with type 2 diabetes

Study type: Systematic review

Dose context: —

Chromium supplementation showed beneficial effects in managing type 2 diabetes mellitus.

Citation: Vajdi et al. (2024). Effects of chromium supplementation on body composition in patients with type 2 diabetes: A dose-response systematic review and meta-analysis of randomized controlled trials.•DOI: 10.18433/J3G022

body composition

Moderate

Population: patients with type 2 diabetes

Study type: Meta-analysis

Dose context: —

Chromium supplementation did not significantly reduce body weight, BMI, or fat mass.

Citation: Pittler et al. (2003). Chromium picolinate for reducing body weight: meta-analysis of randomized trials.•DOI: 10.1016/0026-0495(92)90318-5

insulin resistance

Moderate

Population: women with polycystic ovary syndrome

Study type: Randomized controlled trial

Dose context: —

Chromium picolinate reduced insulin resistance in women with polycystic ovary syndrome.

Citation: Ashoush et al. (2016). Chromium picolinate reduces insulin resistance in polycystic ovary syndrome: Randomized controlled trial.•DOI: 10.1038/nrendo.2011.183

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