The evidence for apigenin mainly comes from studies on chamomile extract, with several trials indicating its effectiveness for anxiety reduction. However, the direct research on isolated apigenin is lacking, and the overall quality of evidence is low to very low.
Anxiety reduction (chamomile extract as apigenin source)Adults with generalized anxiety disorder (GAD) · Systematic review of RCTs (10 trials of chamomile extract)Low
9 of 10 RCTs found chamomile extract effective for anxiety reduction. Long-term chamomile (26 weeks) significantly reduced GAD symptom relapse vs. placebo. Apigenin is a primary active constituent binding the benzodiazepine site of GABA-A receptors.
Sleep quality (dietary apigenin, cohort data)Community-dwelling adults (Italian cohort, n=1,936) · Cross-sectional cohort studyVery low
Dietary apigenin intake inversely associated with inadequate sleep quality (OR 0.63, 95% CI 0.44–0.90); large US cohort also found positive correlation between apigenin intake & sleep quality.
Your personalized stack
Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.
Sleep & Calm Wind-Down
Supports parasympathetic activation before sleep.
Sleep & Recovery Stack
Designed to support sleep quality, parasympathetic activation, & overnight recovery without heavy sedation.
Sleep Quality & Relaxation
GABA & apigenin are combined to improve sleep quality & promote relaxation. GABA is a neurotransmitter that induces calmness, while apigenin has sedative effects that enhance sleep.
Forms & usage▾
Take 50-100 mg of apigenin daily, preferably in the evening.