Sleep Quality & Relaxation

Public • 06 Apr 2026

GABA & apigenin are combined to improve sleep quality & promote relaxation. GABA is a neurotransmitter that induces calmness, while apigenin has sedative effects that enhance sleep.

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Buy stack

sleep relaxation calm

GABA

Before bed

MODERATE

500mg

Apigenin

Before bed

MODERATE

50mg

No interactions detected

Each dose includes evidence rationale · doses personalized to your weight

AI risk assessment

Context: No wearable data

PROAI risk assessment is available with Pro.

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Stack pre-check

No personal data connected — connect wearables or upload bloodwork for a personalised check

Clean

Supplements

Training load

Unknown

No flags

No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis

Pharmacokinetic + pair-level checks

Timing optimizations

GABA

Take ~45 min before the intended effect window

Reaches peak plasma concentration in ~45 min. Half-life ~1h.

Apigenin

Take ~1h before the intended effect window

Reaches peak plasma concentration in ~1h. Half-life ~7h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements

2 items

GABALow

Before bed •

Induces calmness & improves sleep quality.

Buy ingredient →

500mg

Trade-offs & context

Interaction

Additive CNS sedation with benzodiazepines, alcohol, and other sleeping aids

Note

Oral GABA has limited blood-brain-barrier penetration — most supplements act peripherally; central effects may be minimal

Tolerance

Tingling, flushing, or mild shortness of breath at higher doses — generally harmless but can be alarming

Sleep quality / stress / relaxation

Low

Population: Adults with stress or mild insomnia

Study type: RCTs (small)

Dose context: 100 mg typical (range: 100–300 mg) • Duration: Acute to 4 weeks

Some trials show improved sleep latency & subjective relaxation; bioavailability & CNS crossing remain debated.

Citation: Yamatsu et al. 2016; Byun et al. 2018•DOI: 10.1007/s11356-016-6904-x

Often combined with L-theanine or magnesium for sleep stacks.

ApigeninLow

Before bed •

Has sedative effects that enhance sleep.

Buy ingredient →

50mg

Anxiety reduction (chamomile extract as apigenin source)

Low

Population: Adults with generalized anxiety disorder (GAD)

Study type: Systematic review of RCTs (10 trials of chamomile extract)

Dose context: 500 mg typical (range: 220–1500 mg) • Duration: 4–26 weeks

9 of 10 RCTs found chamomile extract effective for anxiety reduction. Long-term chamomile (26 weeks) significantly reduced GAD symptom relapse vs. placebo. Apigenin is a primary active constituent binding the benzodiazepine site of GABA-A receptors.

Citation: Hieu TH et al. Phytother Res. 2019;33(6):1604–1615.•DOI: 10.1002/ptr.6349•https://pubmed.ncbi.nlm.nih.gov/31006899/

Evidence is for chamomile extract, not isolated apigenin. No human RCTs of isolated apigenin for sleep or anxiety exist. GABA-A binding confirmed preclinically (PMID 7617761).

Sleep quality (dietary apigenin, cohort data)

Very low

Population: Community-dwelling adults (Italian cohort, n=1,936)

Study type: Cross-sectional cohort study

Dose context: —

Dietary apigenin intake inversely associated with inadequate sleep quality (OR 0.63, 95% CI 0.44–0.90); large US cohort also found positive correlation between apigenin intake & sleep quality.

Citation: Godos J et al. Nutrients. 2020;12(5):1256.•DOI: 10.3390/nu12051256•https://pubmed.ncbi.nlm.nih.gov/32357534/

Observational data only; no human RCT of isolated apigenin for sleep. Mechanistic support via GABA-A & CD38/NAD+ pathways from preclinical work.

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