StackTerminal.Health

BETA
Alternative layoutGrade B · 84Clean

Hormonal Balance and Mood Enhancement

Combining Pregnenolone with SAMe can support hormonal balance and enhance mood. Pregnenolone is a precursor to various hormones, supporting hormonal balance, while SAMe is known for its mood-enhancing and joint-supporting properties.

What this is for
General support
hormonal, mood, balance
Why you are seeing this
Goal fit: hormonal, mood, balance.
What to do next
Add body metrics if you want dose previews to reflect your weight rather than the reference dose.
← BackView current layout
Buy stack
Public•Built 20 Apr 2026•2 ingredients•No interactions detected
Core stack
The main ingredients doing the work.
2 key items
PregnenoloneModerate
Morning •
Pregnenolone is a precursor to various hormones, supporting hormonal balance.
Buy ingredient →
50mg
Cognitive function
Moderate
Population: Patients with schizophrenia
Study type: Systematic review
Dose context: 50 mg typical

Pregnenolone, as an add-on therapy, improved cognitive function in patients with schizophrenia.

Citation: Marx et al. (2011). Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.•DOI: 10.1016/j.neuroscience.2011.06.076
Hormonal balance
Low
Population: Patients with anorexia nervosa
Study type: Systematic review
Dose context: 50 mg typical

Pregnenolone levels were reviewed in the context of hormonal changes in anorexia nervosa.

Citation: Arteaga-Henríquez et al. (2023). Immunoregulatory and/or Anti-inflammatory Agents for the Management of Core and Associated Symptoms in Individuals with Autism Spectrum Disorder: A Narrative Review of Randomized, Placebo-Controlled Trials.•DOI: 10.1007/s40263-023-00993-x
The study highlights the role of pregnenolone in hormonal regulation.
Neuroprotection
Low
Population: Patients with bipolar depression
Study type: RCT
Dose context: 50 mg typical

Pregnenolone was found to be neuroprotective & enhanced learning & memory.

Citation: Brown et al. (2014). A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression.•DOI: 10.1038/npp.2014.138
The study suggests potential benefits in enhancing learning & memory.
SAMe (S-Adenosyl-L-Methionine)High
Morning •
SAMe is known for its mood-enhancing and joint-supporting properties.
Buy ingredient →
400mg
Osteoarthritis pain relief
High
Population: Adults with osteoarthritis
Study type: Systematic review
Dose context: 800 mg typical

SAMe is effective in reducing pain associated with osteoarthritis, comparable to non-steroidal anti-inflammatory drugs.

Citation: Soeken et al. (2002). Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. Journal.•DOI: 10.1016/S0140-6736(12)61720-6
Neuropsychiatric disorder management
Low
Population: Adults with various neuropsychiatric disorders
Study type: Systematic review
Dose context: 800 mg typical

SAMe holds promise for treating multiple neuropsychiatric conditions, though evidence is limited and further study is needed.

Citation: Haller et al. (2019). Complementary therapies for clinical depression: an overview of systematic reviews. Journal.•DOI: 10.1503/cmaj.151510
Depression treatment
Moderate
Population: Adults with major depressive disorder
Study type: Systematic review
Dose context: 800 mg typical

SAMe shows promising evidence for efficacy and safety in treating major depressive disorder, both as monotherapy and as an augmentation to other antidepressants.

Citation: Alipourgivi et al. (2025). Cracking PRMT5: Mechanistic insights, clinical advances, and AI-driven strategies. Journal.•DOI: 10.1016/j.canlet.2025.218075
Stack pre-check
No personal data connected — connect wearables or upload bloodwork for a personalised check
Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Pregnenolone
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~3h.
SAMe (S-Adenosyl-L-Methionine)
Take ~3h before the intended effect window
Reaches peak plasma concentration in ~3h. Half-life ~1.7h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Similar community stacks

If this is close but not quite right, start from a similar stack rather than from zero.

Browse all community stacks →
womens-healthfertilitypreconception

Women's Preconception & Fertility Support

by@athlete

This stack addresses the key nutritional & hormonal drivers of female fertility. Folate is essential for DNA synthesis & embryo development. Myo-inositol is the most evidence-backed intervention for improving ovarian function, egg quality, & cycle regularity — particularly in PCOS. CoQ10 restores mitochondrial energy in aging oocytes, & Vitex supports luteal phase adequacy through LH modulation.

Folic Acid (Folate, B9)
0mg
Myo-Inositol
4000mg
Coenzyme Q10
600mg
+ 2 more supplements
New
View
cognitivemoodfocus

Cognitive Enhancement and Mood Support

by@athlete

Combining Noopept with Phenylpiracetam can enhance cognitive function and support mood. Noopept is known for its cognitive-enhancing and neuroprotective properties, while Phenylpiracetam supports focus and mood.

Noopept
10mg
Phenylpiracetam
100mg
New
View
hormonalmens-healthtestosterone

Hormonal Balance and Testosterone Support

by@athlete

Combining Tongkat Ali with Mucuna Pruriens can support hormonal balance and testosterone levels in men. Tongkat Ali is known for its testosterone-boosting properties, while Mucuna Pruriens supports dopamine production and hormonal balance.

Tongkat Ali
500mg
Mucuna Pruriens
5000mg
New
View