Pregnenolone

Pregnenolone is a master steroid precursor synthesized from cholesterol, with preliminary evidence suggesting benefits for memory, neuroplasticity, depression, & fatigue through neurosteroid & GABA modulation.

cognitivehormonalmemorymood

Evidence last reviewed: 05 Apr 2026

Buy this ingredient ← Back

Supplement note

Private note on this supplement

Save how you reacted, what dose worked, what to watch for, or anything you want to remember later in your Notes tab.

Biomarkers studied

Outcomes directly measured across the evidence records below

Hormonal

CortisolDHEA / DHEA-S

Cognitive

Cognitive FunctionNeuroprotection / NGFMemory

Evidence

3 records

Cognitive function

Patients with schizophrenia • Systematic review

PUBMEDModerate

Pregnenolone, as an add-on therapy, improved cognitive function in patients with schizophrenia.

Dose: 50 mg

Citation: Marx et al. (2011). Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.

Hormonal balance

Patients with anorexia nervosa • Systematic review

PUBMEDLow

Pregnenolone levels were reviewed in the context of hormonal changes in anorexia nervosa.

Dose: 50 mg

Citation: Arteaga-Henríquez et al. (2023). Immunoregulatory and/or Anti-inflammatory Agents for the Management of Core and Associated Symptoms in Individuals with Autism Spectrum Disorder: A Narrative Review of Randomized, Placebo-Controlled Trials.

The study highlights the role of pregnenolone in hormonal regulation.

Neuroprotection

Patients with bipolar depression • RCT

PUBMEDLow

Pregnenolone was found to be neuroprotective & enhanced learning & memory.

Dose: 50 mg

Citation: Brown et al. (2014). A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression.

The study suggests potential benefits in enhancing learning & memory.

Forms

Capsule

Commonly available in 10 mg to 100 mg dosages.

Tablet

Available in various dosages, often used for precise dosing.

Sublingual

Allows for faster absorption compared to oral forms.

Stacks containing Pregnenolone

Public community stacks that include this ingredient.

Explore all stacks →

hormonalmoodbalance

Hormonal Balance and Mood Enhancement

by@athlete

Combining Pregnenolone with SAMe can support hormonal balance and enhance mood. Pregnenolone is a precursor to various hormones, supporting hormonal balance, while SAMe is known for its mood-enhancing and joint-supporting properties.

Pregnenolone

50mg

SAMe (S-Adenosyl-L-Methionine)

400mg

New

View