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Liver Health and Detoxification

Combining Artichoke Extract with Milk Thistle can support liver health and detoxification. Artichoke Extract promotes bile production, while Milk Thistle is known for its hepatoprotective and antioxidant properties.

What this is for
General support
liver-health, detoxification, antioxidant
Why you are seeing this
Goal fit: liver-health, detoxification, antioxidant.
What to do next
Add body metrics if you want dose previews to reflect your weight rather than the reference dose.
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Public•Built 20 Apr 2026•2 ingredients•No interactions detected
Core stack
The main ingredients doing the work.
2 key items
Artichoke Leaf ExtractLow
Daily with meals •
Artichoke Extract promotes bile production for liver health.
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320mg
Metabolic parameter improvement
Low
Population: Women with metabolic syndrome
Study type: RCT
Dose context: 320 mg typical

Artichoke leaf extract supplementation showed beneficial effects on metabolic parameters.

Citation: Rezazadeh et al. (2018). Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms. Journal.•DOI: 10.1002/ptr.5951
Cholesterol reduction
High
Population: Patients with hypercholesterolemia
Study type: Systematic review and meta-analysis
Dose context: 320 mg typical

Artichoke leaf extract supplementation significantly decreased plasma concentrations of total cholesterol & LDL-C.

Citation: Wauquier et al. (2021). Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial. Journal.•DOI: 10.3390/nu13082653
Liver function improvement
Moderate
Population: Patients with non-alcoholic fatty liver disease
Study type: RCT
Dose context: 600 mg typical (range: 600–600 mg) • Duration: 2 months

Artichoke leaf extract showed potential as a hepatoprotective agent, improving liver function markers.

Citation: Panahi et al. (2018). Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Journal.•DOI: 10.1002/ptr.6073
Milk Thistle (Silymarin)Moderate
Daily with meals •
Milk Thistle is known for its hepatoprotective and antioxidant properties.
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500mg
Liver histology improvement
Moderate
Population: Patients with NAFLD
Study type: RCT
Dose context: 420 mg typical

Silymarin improved liver histology in NAFLD patients, though further research is needed.

Citation: Wah Kheong et al. (2017). A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis. Clinical Gastroenterology and Hepatology.•DOI: 10.1016/j.cgh.2017.04.016
Liver enzyme reduction
Moderate
Population: Patients with NAFLD
Study type: Systematic review
Dose context: 420 mg typical

Silymarin significantly reduced liver enzymes ALT & AST, indicating improved liver function.

Citation: Soleimani et al. (2019). Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytotherapy Research.•DOI: 10.1002/ptr.6361
Reduction in oxidative stress
Low
Population: General population
Study type: Systematic review
Dose context: 420 mg typical

Silymarin exhibits antioxidant properties that may reduce oxidative stress.

Citation: Horowitz et al. (2022). Silibinin: a toxicologist's herbal medicine?. Clinical Toxicology.•DOI: 10.1080/15563650.2022.2128815
Based on preclinical data & historical use.
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Supplements
2
Training load
Unknown
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No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Milk Thistle (Silymarin)
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~6h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

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