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Liver Health and Detoxification

B84· Mostly solid
Public • 20 Apr 2026

Combining Artichoke Extract with Milk Thistle can support liver health and detoxification. Artichoke Extract promotes bile production, while Milk Thistle is known for its hepatoprotective and antioxidant properties.

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Liver Health and Detoxification
liver-healthdetoxificationantioxidant
Artichoke Leaf Extract
Daily with meals
MODERATE
320mg
Milk Thistle (Silymarin)
Daily with meals
MODERATE
500mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
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2
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Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Milk Thistle (Silymarin)
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~6h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
Artichoke Leaf ExtractLow
Daily with meals •
Artichoke Extract promotes bile production for liver health.
Buy ingredient →
320mg
Metabolic parameter improvement
Low
Population: Women with metabolic syndrome
Study type: RCT
Dose context: 320 mg typical

Artichoke leaf extract supplementation showed beneficial effects on metabolic parameters.

Citation: Rezazadeh et al. (2018). Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms. Journal.•DOI: 10.1002/ptr.5951
Cholesterol reduction
High
Population: Patients with hypercholesterolemia
Study type: Systematic review and meta-analysis
Dose context: 320 mg typical

Artichoke leaf extract supplementation significantly decreased plasma concentrations of total cholesterol & LDL-C.

Citation: Wauquier et al. (2021). Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial. Journal.•DOI: 10.3390/nu13082653
Liver function improvement
Moderate
Population: Patients with non-alcoholic fatty liver disease
Study type: RCT
Dose context: 600 mg typical (range: 600–600 mg) • Duration: 2 months

Artichoke leaf extract showed potential as a hepatoprotective agent, improving liver function markers.

Citation: Panahi et al. (2018). Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Journal.•DOI: 10.1002/ptr.6073
Milk Thistle (Silymarin)Moderate
Daily with meals •
Milk Thistle is known for its hepatoprotective and antioxidant properties.
Buy ingredient →
500mg
Liver histology improvement
Moderate
Population: Patients with NAFLD
Study type: RCT
Dose context: 420 mg typical

Silymarin improved liver histology in NAFLD patients, though further research is needed.

Citation: Wah Kheong et al. (2017). A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis. Clinical Gastroenterology and Hepatology.•DOI: 10.1016/j.cgh.2017.04.016
Liver enzyme reduction
Moderate
Population: Patients with NAFLD
Study type: Systematic review
Dose context: 420 mg typical

Silymarin significantly reduced liver enzymes ALT & AST, indicating improved liver function.

Citation: Soleimani et al. (2019). Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytotherapy Research.•DOI: 10.1002/ptr.6361
Reduction in oxidative stress
Low
Population: General population
Study type: Systematic review
Dose context: 420 mg typical

Silymarin exhibits antioxidant properties that may reduce oxidative stress.

Citation: Horowitz et al. (2022). Silibinin: a toxicologist's herbal medicine?. Clinical Toxicology.•DOI: 10.1080/15563650.2022.2128815
Based on preclinical data & historical use.

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