Milk Thistle (Silymarin)
Milk Thistle is a hepatoprotective supplement that helps stabilize liver cell membranes & stimulate liver protein synthesis, beneficial for individuals with liver conditions such as alcoholic liver disease & nonalcoholic fatty liver disease (NAFLD).
Evidence last reviewed: 05 Apr 2026
The evidence suggests that Milk Thistle may improve liver function and insulin sensitivity, particularly in individuals with liver conditions like NAFLD. However, the strength of the evidence varies, and further studies are needed to confirm these benefits.
Liver histology improvementPatients with NAFLD · RCTModerate
Silymarin improved liver histology in NAFLD patients, though further research is needed.
Reduction in oxidative stressGeneral population · Systematic reviewLow
Silymarin exhibits antioxidant properties that may reduce oxidative stress.
Liver fibrosis reductionPatients with NASH · RCTModerate
Silymarin reduced liver fibrosis in patients with NASH, although not significantly more than placebo for NAS score reduction.
Improvement in insulin sensitivityPatients with insulin resistance · Systematic reviewModerate
Silymarin improved insulin sensitivity & reduced insulin resistance markers.
Liver enzyme reductionPatients with NAFLD · Systematic reviewModerate
Silymarin significantly reduced liver enzymes ALT & AST, indicating improved liver function.
Liver Detox & Protection
Milk thistle & calcium d-glucarate are combined to support liver detoxification & protection. Milk thistle is known for its hepatoprotective properties, while calcium d-glucarate aids in detoxification processes.
Liver Health and Detoxification
Combining Artichoke Extract with Milk Thistle can support liver health and detoxification. Artichoke Extract promotes bile production, while Milk Thistle is known for its hepatoprotective and antioxidant properties.
Forms & usage▾
Take 150-300 mg of silymarin daily, preferably with meals.