StackTerminal.Health

BETA

Endurance & Performance Boost

Public • 06 Apr 2026

L-arginine & sodium bicarbonate are combined to enhance endurance & performance. L-arginine supports nitric oxide production, improving blood flow, while sodium bicarbonate buffers lactic acid, reducing fatigue during exercise.

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Endurance & Performance Boost
enduranceperformancestrength
L-Arginine
30 min pre-workout
MODERATE
3000mg
Sodium Bicarbonate
30 min pre-workout
MODERATE
500mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
AI risk assessment
Context: No wearable data
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Stack pre-check
No personal data connected — connect wearables or upload bloodwork for a personalised check
Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
L-Arginine
Take ~1h before the intended effect window
Reaches peak plasma concentration in ~1h. Half-life ~1.5h.
Sodium Bicarbonate
Take ~1h before the intended effect window
Reaches peak plasma concentration in ~1h. Half-life ~1h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
L-ArginineModerate
30 min pre-workout •
Supports nitric oxide production, improving blood flow.
Buy ingredient →
3000mg
endurance exercise performance
Moderate
Population: general population
Study type: Systematic review and meta-analysis
Dose context: 6000 mg typical

L-Arginine supplementation may enhance endurance exercise performance by increasing nitric oxide bioavailability.

Citation: d'Unienville et al. (2021). Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance. Preventive Medicine.•DOI: 10.1016/0091-7435(91)90006-P
erectile dysfunction
Moderate
Population: men with erectile dysfunction
Study type: Systematic review and meta-analysis
Dose context: 6000 mg typical

L-Arginine supplementation showed potential benefits in improving erectile function.

Citation: Rhim et al. (2019). The Potential Role of Arginine Supplements on Erectile Dysfunction. Journal of the American College of Cardiology.•DOI: 10.1016/j.jacc.2007.11.044
blood pressure
Moderate
Population: women with hypertensive disorders of pregnancy
Study type: Systematic review
Dose context: 6000 mg typical

L-Arginine supplementation reduced blood pressure & the need for antihypertensive drugs.

Citation: Gokce et al. (2004). L-arginine and hypertension. American Journal of Physiology.•DOI: 10.1152/ajpheart.00396.2018
Sodium BicarbonateHigh
30 min pre-workout •
Buffers lactic acid, reducing fatigue during exercise.
Buy ingredient →
500mg
Trade-offs & context
Tolerance

GI distress (nausea, vomiting, diarrhea) affects the majority of users at full doses — split dosing or enteric-coated capsules reduce this significantly

Cardiovascular

High sodium load — not suitable for those on sodium-restricted diets or with unmanaged hypertension

High-intensity & repeated sprint performance
High
Population: Athletes; trained individuals
Study type: Meta-analyses of RCTs
Dose context: 17500 mg typical (range: 14000–21000 mg) • Duration: Acute (60–90 min pre-exercise)

1–3% improvement in high-intensity performance lasting 1–7 min; strong effect on repeated sprints.

Citation: Lopes-Silva et al. 2018 (meta); Carr et al. 2011•DOI: 10.1080/02640414.2018.1524739
GI distress common; start with lower dose; enteric coating helps.
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