L-Arginine
L-Arginine is a semi-essential amino acid that serves as a precursor to nitric oxide, supporting vascular function, blood flow, & exercise performance, particularly beneficial for cardiovascular health & endurance athletes.
Evidence last reviewed: 05 Apr 2026
Moderate evidence suggests L-Arginine may enhance endurance performance, improve maternal and fetal outcomes, and reduce blood pressure in specific populations. However, more research is needed to fully understand its effects across diverse groups.
endurance exercise performancegeneral population · Systematic review and meta-analysisModerate
L-Arginine supplementation may enhance endurance exercise performance by increasing nitric oxide bioavailability.
erectile dysfunctionmen with erectile dysfunction · Systematic review and meta-analysisModerate
L-Arginine supplementation showed potential benefits in improving erectile function.
blood pressurewomen with hypertensive disorders of pregnancy · Systematic reviewModerate
L-Arginine supplementation reduced blood pressure & the need for antihypertensive drugs.
maternal & fetal outcomespregnant women · Systematic reviewModerate
L-Arginine supplementation improved fetoplacental circulation & birth weight.
Endurance & Performance Boost
L-arginine & sodium bicarbonate are combined to enhance endurance & performance. L-arginine supports nitric oxide production, improving blood flow, while sodium bicarbonate buffers lactic acid, reducing fatigue during exercise.
Forms & usage▾
Take 3–6 grams daily, ideally before exercise or meals.