StackTerminal.Health

BETA

Athletic Performance Enhancement

Public • 06 Apr 2026

Betaine anhydrous & l-citrulline are combined to enhance athletic performance & endurance. Betaine anhydrous supports strength & power, while l-citrulline aids in nitric oxide production, improving blood flow & endurance.

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Athletic Performance Enhancement
performanceendurancestrength
Betaine Anhydrous
30 min pre-workout
MODERATE
2500mg
L-Citrulline
30 min pre-workout
MODERATE
6000mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
AI risk assessment
Context: No wearable data
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Stack pre-check
No personal data connected — connect wearables or upload bloodwork for a personalised check
Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
L-Citrulline
60 min pre-workout
Tmax ~1h. Plasma nitric oxide elevation peaks 60–90 min post-ingestion. (Onset: ~1h, half-life: ~1.5h)

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
Betaine AnhydrousModerate
30 min pre-workout •
Supports strength & power during workouts.
Buy ingredient →
2500mg
serum betaine concentration
Moderate
Population: resistance-trained men
Study type: RCT
Dose context: 6000 mg typical (range: 6000–6000 mg) • Duration: 14 days

The study determined that a 28-day washout period was sufficient to return serum betaine concentrations to baseline after supplementation.

Citation: Machek et al. (2022). Human Serum Betaine and Associated Biomarker Concentrations Following a 14 Day Supplemental Betaine Loading Protocol and during a 28 Day Washout Period: A Pilot Investigation. Nutrients.•DOI: 10.3390/nu14030498
muscular endurance
Moderate
Population: recreationally trained males
Study type: RCT
Dose context: 6000 mg typical (range: 6000–6000 mg) • Duration: 14 days

Betaine supplementation combined with blood flow restriction training improved one-leg press performance & affected exercise-associated biomarkers.

Citation: Machek et al. (2022). The Impacts of Combined Blood Flow Restriction Training and Betaine Supplementation on One-Leg Press Muscular Endurance, Exercise-Associated Lactate Concentrations, Serum Metabolic Biomarkers, and Hypoxia-Inducible Factor-1α Gene Expression. European Journal of Applied Physiology.•DOI: 10.1007/s00421-012-2492-8
liver biochemistries & histological markers
Low
Population: patients with nonalcoholic steatohepatitis
Study type: Pilot study
Dose context: 2500 mg typical

Betaine was shown to raise S-adenosylmethionine levels, potentially decreasing hepatic steatosis in patients with nonalcoholic steatohepatitis.

Citation: Abdelmalek et al. (2001). Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Journal of Clinical Medicine.•DOI: 10.1016/j.jcm.2012.11.001
L-CitrullineModerate
30 min pre-workout •
Aids in nitric oxide production, improving blood flow & endurance.
Buy ingredient →
6000mg
Blood pressure
Moderate
Population: Hypertensive postmenopausal women
Study type: Systematic review
Dose context: 6000 mg typical

L-Citrulline supplementation improved endothelial function & reduced blood pressure.

Citation: Maharaj et al. (2022). Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.•DOI: 10.3200/JACH.57.1.33-38
Endurance performance
Moderate
Population: Young adult trained males
Study type: RCT
Dose context: 6000 mg typical

L-Citrulline supplementation showed potential benefits for endurance performance.

Citation: Cabre et al. (2023). The effects of L-Citrulline and Glutathione on Endurance performance in young adult trained males.•DOI: 10.1016/S0140-6736(25)00397-6
Blood pressure
Moderate
Population: Middle-aged and older adults
Study type: Systematic review and meta-analysis
Dose context: 6000 mg typical

L-Citrulline supplementation was associated with reduced blood pressure.

Citation: Luo et al. (2025). Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.•DOI: 10.1161/CIRCRESAHA.115.306825
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