Athletic Performance and Endurance

B84· Mostly solid

Public • 20 Apr 2026

Combining Betaine Anhydrous with Cordyceps can enhance athletic performance and endurance. Betaine supports strength and power output, while Cordyceps improves oxygen utilization and endurance.

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Athletic Performance and Endurance

performance endurance recovery

Betaine Anhydrous

30 min pre-workout

MODERATE

2500mg

Cordyceps (Ophiocordyceps sinensis / militaris)

30 min pre-workout

MODERATE

1000mg

No interactions detected

Each dose includes evidence rationale · doses personalized to your weight

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Clean

Supplements

Training load

Unknown

No flags

No duplication, stimulant, interaction, or recovery concerns detected.

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Interaction Analysis

Pharmacokinetic + pair-level checks

No interactions detected

No known absorption conflicts, pharmacokinetic conflicts, or synergies found between the ingredients in this stack.

Supplements

2 items

Betaine AnhydrousModerate

30 min pre-workout •

Betaine supports strength and power output.

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2500mg

serum betaine concentration

Moderate

Population: resistance-trained men

Study type: RCT

Dose context: 6000 mg typical (range: 6000–6000 mg) • Duration: 14 days

The study determined that a 28-day washout period was sufficient to return serum betaine concentrations to baseline after supplementation.

Citation: Machek et al. (2022). Human Serum Betaine and Associated Biomarker Concentrations Following a 14 Day Supplemental Betaine Loading Protocol and during a 28 Day Washout Period: A Pilot Investigation. Nutrients.•DOI: 10.3390/nu14030498

muscular endurance

Moderate

Population: recreationally trained males

Study type: RCT

Dose context: 6000 mg typical (range: 6000–6000 mg) • Duration: 14 days

Betaine supplementation combined with blood flow restriction training improved one-leg press performance & affected exercise-associated biomarkers.

Citation: Machek et al. (2022). The Impacts of Combined Blood Flow Restriction Training and Betaine Supplementation on One-Leg Press Muscular Endurance, Exercise-Associated Lactate Concentrations, Serum Metabolic Biomarkers, and Hypoxia-Inducible Factor-1α Gene Expression. European Journal of Applied Physiology.•DOI: 10.3390/nu14235040

liver biochemistries & histological markers

Low

Population: patients with nonalcoholic steatohepatitis

Study type: Pilot study

Dose context: 2500 mg typical

Betaine was shown to raise S-adenosylmethionine levels, potentially decreasing hepatic steatosis in patients with nonalcoholic steatohepatitis.

Citation: Abdelmalek et al. (2001). Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Journal of Clinical Medicine.•DOI: 10.1016/s0002-9270(01)02691-0

Cordyceps (Ophiocordyceps sinensis / militaris)Low

30 min pre-workout •

Cordyceps improves oxygen utilization and endurance.

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1000mg

Aerobic exercise capacity & VO2max

Low

Population: Healthy young adults

Study type: RCT

Dose context: 2000 mg typical (range: 1000–4000 mg) • Duration: 3 weeks

A 3-week RCT of a Cordyceps militaris-containing mushroom blend found VO2max significantly improved (+4.8 ml/kg/min; p=0.042) & time to exhaustion increased (+69.8 s) compared to placebo; acute supplementation (1 week) showed no effect, suggesting chronic dosing is required.

Citation: Hirsch KR, Smith-Ryan AE, Roelofs EJ, Trexler ET, Mock MG. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl. 2017;14(1):42-53.•DOI: 10.1080/19390211.2016.1203386•https://pubmed.ncbi.nlm.nih.gov/27408987/

Metabolic threshold & ventilatory threshold during exercise

Low

Population: Healthy older adults (ages 50–75)

Study type: double-blind placebo-controlled RCT

Dose context: 1000 mg typical (range: 999–999 mg) • Duration: 12 weeks

A 12-week RCT of Cs-4 (Cordyceps sinensis) at 999 mg/day in 20 healthy older adults improved metabolic threshold by 10.5% (p<0.02) & ventilatory threshold by 8.5% (p=0.031) versus placebo; VO2max did not change significantly.

Citation: Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. J Altern Complement Med. 2010;16(5):585-90.•DOI: 10.1089/acm.2009.0226•https://pubmed.ncbi.nlm.nih.gov/20804368/

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