StackTerminal.Health

BETA
Alternative layoutGrade B · 87Clean with useful synergies

Thyroid & Hormonal Support

Iodine & selenium are combined to support thyroid function & hormonal balance. Iodine is essential for thyroid hormone production, while selenium supports thyroid health & antioxidant defense.

What this is for
General support
thyroid, hormonal, energy
Why you are seeing this
Goal fit: thyroid, hormonal, energy.
What to do next
Add body metrics if you want dose previews to reflect your weight rather than the reference dose.
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Public•Built 06 Apr 2026•2 ingredients•No interactions detected · 1 synergy found
Core stack
The main ingredients doing the work.
2 key items
IodineLow
Daily with food •
Essential for thyroid hormone production.
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150mg
Child development outcomes (cretinism prevention, motor/cognitive) in relation to prenatal iodine
Low
Population: Pregnant women and their offspring across iodine-status populations
Study type: systematic review of RCTs
Dose context: — • Duration: during pregnancy

Systematic review of 8 RCTs found that in areas of severe iodine deficiency, supplementation reduced cretinism risk & showed some motor development benefits; in mild-to-moderate deficiency areas, no RCTs provided data on childhood cognitive or developmental outcomes; effects on maternal thyroid function were inconsistent.

Citation: Zhou SJ, Anderson AJ, Gibson RA, Makrides M. Effect of iodine supplementation in pregnancy on child development and other clinical outcomes: a systematic review of randomized controlled trials. Am J Clin Nutr. 2013;98(5):1241-54.•DOI: 10.3945/ajcn.113.065854•https://pubmed.ncbi.nlm.nih.gov/24025628/
Thyroid function & child neurodevelopment in mildly deficient pregnancy
Low
Population: Pregnant women with mild-to-moderate iodine deficiency
Study type: systematic review and meta-analysis of RCTs
Dose context: — • Duration: pregnancy duration

A systematic review of 10 RCTs & 23 observational studies found inconsistent effects of iodine supplementation on maternal or infant TSH & no significant improvement in childhood cognitive, language, or motor scores; authors concluded evidence is insufficient to support universal supplementation in mild-to-moderate deficiency regions but supplementation remains important in severe deficiency.

Citation: Dineva M, Fishpool H, Rayman MP, Mendis J, Bath SC. Systematic review and meta-analysis of the effects of iodine supplementation on thyroid function and child neurodevelopment in mildly-to-moderately iodine-deficient pregnant women. Am J Clin Nutr. 2020;112(2):389-412.•DOI: 10.1093/ajcn/nqaa071•https://pubmed.ncbi.nlm.nih.gov/32320029/
Dose in mg (150 mcg = 0.15 mg). WHO recommends 250 mcg/day during pregnancy. Benefits are most clear in severely iodine-deficient populations.
SeleniumModerate
Daily with food •
Supports thyroid health & antioxidant defense.
Buy ingredient →
100mg
Thyroid function, selenium biochemistry, & immune parameters
Moderate
Population: General population and patients with thyroid disorders
Study type: review
Dose context: — • Duration: ongoing

A comprehensive review confirmed that the thyroid gland contains the highest selenium concentration per gram of any organ; selenium is indispensable for the synthesis of thyroid hormones (as deiodinase cofactor), & deficiency impairs T4-to-T3 conversion; supplementation in autoimmune thyroiditis reduces antibody titers & may improve quality of life.

Citation: Ventura M, Melo M, Carrilho F. Selenium and Thyroid Disease: From Pathophysiology to Treatment. Int J Endocrinol. 2017;2017:1297658.•DOI: 10.1155/2017/1297658•https://pubmed.ncbi.nlm.nih.gov/28255299/
Thyroid antibodies (TPOAb) & thyroid function in Hashimoto thyroiditis
Moderate
Population: Adults with Hashimoto autoimmune thyroiditis
Study type: systematic review and meta-analysis of RCTs
Dose context: — • Duration: 3–12 months

Meta-analysis of 35 RCTs (n=2,358) found selenium supplementation significantly decreased TPOAb levels in patients not on thyroid hormone replacement, lowered TSH, & reduced malondialdehyde; adverse effects were comparable to placebo (moderate certainty of evidence).

Citation: Huwiler VV, Marti-Soler H, Hapfelmeier A, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34(3):295-313.•DOI: 10.1089/thy.2023.0556•https://pubmed.ncbi.nlm.nih.gov/38243784/
Dose expressed in mg (200 mcg = 0.2 mg). Organic selenium forms (selenomethionine) preferred over inorganic forms.
Stack pre-check
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Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
1 synergyNo conflicts
Synergies detected
Synergy
Selenium + Iodine: thyroid hormone synergy
Iodine is the structural component of thyroid hormones (T3/T4); selenium-dependent deiodinases convert inactive T4 to active T3. Selenium also protects thyroid tissue from hydrogen peroxide damage generated during hormone synthesis. Both must be adequate for optimal thyroid output.
→Ensure both are adequate, not excessive: 55–200mcg selenium + 150mcg iodine (RDA). Mega-dosing either can be counter-productive.
Timing optimizations
Iodine
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~10h.
Selenium
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~24h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

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