Selenium
Selenium is an essential trace mineral incorporated into selenoproteins including glutathione peroxidase & thioiodothyronine deiodinases; the thyroid contains the highest selenium concentration per gram of any tissue, & supplementation reduces thyroid antibodies & supports hormone synthesis in deficient individuals.
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A comprehensive review confirmed that the thyroid gland contains the highest selenium concentration per gram of any organ; selenium is indispensable for the synthesis of thyroid hormones (as deiodinase cofactor), & deficiency impairs T4-to-T3 conversion; supplementation in autoimmune thyroiditis reduces antibody titers & may improve quality of life.
Meta-analysis of 35 RCTs (n=2,358) found selenium supplementation significantly decreased TPOAb levels in patients not on thyroid hormone replacement, lowered TSH, & reduced malondialdehyde; adverse effects were comparable to placebo (moderate certainty of evidence).
Stacks containing Selenium
Public community stacks that include this ingredient.
Men's Sperm Quality & Testosterone Stack
Male factor infertility accounts for ~50% of cases & is largely driven by oxidative stress, micronutrient deficiency, & suboptimal testosterone. Ashwagandha has RCT evidence for significantly improving sperm concentration, motility, & testosterone. L-carnitine is the most evidence-backed intervention for sperm motility. CoQ10 & selenium reduce seminal oxidative damage, while zinc is essential for spermatogenesis & androgen synthesis.
Thyroid & Hormonal Support
Iodine & selenium are combined to support thyroid function & hormonal balance. Iodine is essential for thyroid hormone production, while selenium supports thyroid health & antioxidant defense.