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BETA

Liver Detox & Protection

Public • 06 Apr 2026

Milk thistle & calcium d-glucarate are combined to support liver detoxification & protection. Milk thistle is known for its hepatoprotective properties, while calcium d-glucarate aids in detoxification processes.

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Liver Detox & Protection
liverdetoxificationantioxidant
Milk Thistle (Silymarin)
Daily with meals
MODERATE
420mg
Calcium D-Glucarate
Daily with meals
MODERATE
500mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
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Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Milk Thistle (Silymarin)
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~6h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
Milk Thistle (Silymarin)Moderate
Daily with meals •
Provides hepatoprotective properties for liver health.
Buy ingredient →
420mg
Liver enzyme reduction
Moderate
Population: Patients with NAFLD
Study type: Systematic review
Dose context: 420 mg typical

Silymarin significantly reduced liver enzymes ALT & AST, indicating improved liver function.

Citation: Soleimani et al. (2019). Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytotherapy Research.•DOI: 10.1002/ptr.6361
Liver histology improvement
Moderate
Population: Patients with NAFLD
Study type: RCT
Dose context: 420 mg typical

Silymarin improved liver histology in NAFLD patients, though further research is needed.

Citation: Wah Kheong et al. (2017). A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis. Clinical Gastroenterology and Hepatology.•DOI: 10.1016/j.cgh.2017.04.016
Improvement in insulin sensitivity
Moderate
Population: Patients with insulin resistance
Study type: Systematic review
Dose context: 420 mg typical

Silymarin improved insulin sensitivity & reduced insulin resistance markers.

Citation: Yin et al. (2025). Effects of silymarin on insulin resistance and sensitivity: A systematic review and meta-analysis of randomized controlled trials.•DOI: 10.3389/fendo.2022.1089938
Calcium D-GlucarateVery low
Daily with meals •
Aids in detoxification processes in the liver.
Buy ingredient →
500mg
Liver health
Very low
Population: General population
Study type: Theoretical
Dose context: 1500 mg typical (range: 500–3000 mg)

May support liver health by aiding in the detoxification process.

Citation: No specific study available.
Based on its role in detoxification.
Estrogen detoxification
Very low
Population: General population
Study type: Theoretical
Dose context: 1500 mg typical (range: 500–3000 mg)

Calcium D-Glucarate may support estrogen detoxification by inhibiting beta-glucuronidase, reducing the reabsorption of estrogen.

Citation: No specific study available.
Based on known pharmacological action of inhibiting beta-glucuronidase.
Cancer prevention
Very low
Population: General population
Study type: Theoretical
Dose context: 1500 mg typical (range: 500–3000 mg)

Potential role in cancer prevention through detoxification pathways, though direct evidence is lacking.

Citation: No specific study available.
Hypothesized based on detoxification properties.
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