StackTerminal.Health

BETA

Endurance Nitric Oxide Base

B84· Mostly solid
Public • 04 Feb 2026

Targets blood flow & exercise efficiency.

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Endurance Nitric Oxide Base
endurancenitric-oxideperformance
Beetroot Juice (Nitrate)
Daily
MODERATE
500mg
L-Citrulline Malate
Daily
MODERATE
8000mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
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Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Beetroot Juice / Dietary Nitrate
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~6.5h.
L-Citrulline Malate
60 min pre-workout
Tmax ~1h. Plasma nitric oxide elevation peaks 60–90 min post-ingestion. (Onset: ~45 min, half-life: ~1.5h)

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
Beetroot Juice (Nitrate)Moderate
Daily •
Buy ingredient →
500mg
Exercise performance (constant-load & time-trial)
Moderate
Population: Healthy, recreationally active adults; sub-elite more than elite
Study type: Systematic review & meta-analysis
Dose context: 400 mg typical (range: 300–600 mg) • Duration: Acute to chronic (≥3 days)

Significant improvement in exercise performance (d = 0.17, 95% CI 0.12–0.23; p<0.001) across 80 studies; greatest benefit in constant-power tests & sub-elite populations.

Citation: Hoon MW et al. Int J Sport Nutr Exerc Metab. 2013;23(5):522–532.•DOI: 10.1123/ijsnem.23.5.522•https://pubmed.ncbi.nlm.nih.gov/23580439/
Optimal acute dose: 5–15 mmol NO3−, ≥2–3 h pre-exercise.
Ergogenic effects of nitrate across sport types & populations
Moderate
Population: Athletes and active adults (80 studies)
Study type: Systematic review & meta-analysis
Dose context: 400 mg typical (range: 300–800 mg) • Duration: Acute to chronic

Consistent ergogenic effect across aerobic performance measures; effects moderated by fitness level, inspired O2 fraction, & biological sex.

Citation: Senefeld JW et al. Med Sci Sports Exerc. 2020;52(10):2250–2261.•DOI: 10.1249/MSS.0000000000002363•https://pubmed.ncbi.nlm.nih.gov/32936597/
Elite athletes show smaller or no effect; benefit most reliable in recreationally trained individuals.
L-Citrulline MalateModerate
Daily •
Buy ingredient →
8000mg
Aerobic exercise performance / oxygen kinetics / RPE
Moderate
Population: Recreationally active and trained adults
Study type: Systematic review & meta-analysis
Dose context: 6000 mg typical (range: 3000–9000 mg) • Duration: Acute to 7 days

Positive impact on aerobic performance outcomes including lactate, VO2 kinetics, & perceived exertion via nitric oxide-mediated vasodilation; results mixed, effect sizes small.

Citation: Viribay A et al. Nutrients. 2022;14(17):3479.•DOI: 10.3390/nu14173479•https://pubmed.ncbi.nlm.nih.gov/36079738/
Ergogenic effects more consistent for resistance than large-muscle endurance tasks.
Systolic blood pressure reduction
Moderate
Population: Adults; mixed health status (8 trials)
Study type: Systematic review & meta-analysis
Dose context: 6000 mg typical (range: 3000–9000 mg) • Duration: 1–17 weeks

Pooled reduction of −4.1 mmHg systolic BP (95% CI −7.94 to −0.26); diastolic reduction significant only at ≥6 g/day.

Citation: Barkhidarian B et al. J Hum Hypertens. 2019;33(1):10–21.•DOI: 10.1038/s41371-018-0113-1•https://pubmed.ncbi.nlm.nih.gov/30788274/
Antihypertensive effect modest; most consistent with doses ≥6 g/day.
Resistance exercise repetitions to failure
Moderate
Population: Resistance-trained adults
Study type: Systematic review & meta-analysis
Dose context: 8000 mg typical (range: 6000–8000 mg) • Duration: Acute (single dose pre-exercise)

Significant benefit for total repetitions to failure vs. placebo (SMD = 0.20, p = 0.036) with citrulline malate; 8 g acutely prior to upper/lower body resistance exercise.

Citation: Trexler ET et al. Eur J Sport Sci. 2021;21(9):1229–1238.•https://pubmed.ncbi.nlm.nih.gov/34010809/
Pérez-Guisado & Jakeman 2010 RCT (PMID 20386132) found ~52% more bench press reps with 8 g CM vs. placebo.

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