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L-Citrulline Malate

Precursor to arginine & nitric oxide; used to support blood flow, reduce fatigue, & improve exercise performance.

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Evidence last reviewed: 04 Apr 2026

Evidence
3 records
3 recordsBest grade:Moderate
Biomarkers
VO₂ MaxBlood PressureAerobic Capacity

The evidence suggests L-Citrulline Malate can reduce systolic blood pressure and improve both aerobic and resistance exercise performance. While the findings are moderate, more research could further clarify its effects across different populations.

Aerobic exercise performance / oxygen kinetics / RPE
Recreationally active and trained adults · Systematic review & meta-analysis
Moderate

Positive impact on aerobic performance outcomes including lactate, VO2 kinetics, & perceived exertion via nitric oxide-mediated vasodilation; results mixed, effect sizes small.

Dose: 6000 mgDuration: Acute to 7 days
Ergogenic effects more consistent for resistance than large-muscle endurance tasks.
Systolic blood pressure reduction
Adults; mixed health status (8 trials) · Systematic review & meta-analysis
Moderate

Pooled reduction of −4.1 mmHg systolic BP (95% CI −7.94 to −0.26); diastolic reduction significant only at ≥6 g/day.

Dose: 6000 mgDuration: 1–17 weeks
Antihypertensive effect modest; most consistent with doses ≥6 g/day.
Resistance exercise repetitions to failure
Resistance-trained adults · Systematic review & meta-analysis
Moderate

Significant benefit for total repetitions to failure vs. placebo (SMD = 0.20, p = 0.036) with citrulline malate; 8 g acutely prior to upper/lower body resistance exercise.

Dose: 8000 mgDuration: Acute (single dose pre-exercise)Form: MalateTiming: pre-exercise
Pérez-Guisado & Jakeman 2010 RCT (PMID 20386132) found ~52% more bench press reps with 8 g CM vs. placebo.
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Community Insights
Forms & usage
How to take it

Take 6–8 grams before exercise, ideally mixed with water.

Citrulline malate (2:1)
Most common form in sports research; 8 g CM ≈ 5 g L-citrulline.
L-citrulline (pure)
Higher citrulline content per gram.
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