StackTerminal.Health

Apigenin

Flavonoid found in chamomile; binds GABA-A receptors with mild anxiolytic/sedative properties. Direct human trials on isolated apigenin are lacking; evidence primarily from chamomile extract RCTs.

sleepstressanxiety
Dosing model
FLATFixed dose (no body-weight scaling).
Min dose
50 mg
Max dose
200 mg
Rounding
25 mg
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Stacks containing Apigenin

Public community stacks that include this ingredient.

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recoverysleep

Sleep & Recovery Stack

by@athlete

Designed to support sleep quality, parasympathetic activation, and overnight recovery without heavy sedation.

Magnesium Glycinate
400mg
Glycine
3000mg
L-Theanine
200mg
+ 1 more supplements
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sleep

Sleep & Calm Wind-Down

by@athlete

Supports parasympathetic activation before sleep.

Apigenin
50mg
Glycine
3000mg
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View
Evidence
2 records
Anxiety reduction (chamomile extract as apigenin source)
Adults with generalized anxiety disorder (GAD) • Systematic review of RCTs (10 trials of chamomile extract)
Low

9 of 10 RCTs found chamomile extract effective for anxiety reduction. Long-term chamomile (26 weeks) significantly reduced GAD symptom relapse vs. placebo. Apigenin is a primary active constituent binding the benzodiazepine site of GABA-A receptors.

Dose: 500 mg • Duration: 4–26 weeks
Citation: Hieu TH et al. Phytother Res. 2019;33(6):1604–1615.
Evidence is for chamomile extract, not isolated apigenin. No human RCTs of isolated apigenin for sleep or anxiety exist. GABA-A binding confirmed preclinically (PMID 7617761).
Sleep quality (dietary apigenin, cohort data)
Community-dwelling adults (Italian cohort, n=1,936) • Cross-sectional cohort study
Very low

Dietary apigenin intake inversely associated with inadequate sleep quality (OR 0.63, 95% CI 0.44–0.90); large US cohort also found positive correlation between apigenin intake and sleep quality.

Dose: —
Citation: Godos J et al. Nutrients. 2020;12(5):1256.
Observational data only; no human RCT of isolated apigenin for sleep. Mechanistic support via GABA-A and CD38/NAD+ pathways from preclinical work.
Forms
Apigenin (from chamomile or synthetic)
Chamomile extract is ~1% apigenin by mass; isolated apigenin used in most modern supplements.