Apigenin
Flavonoid found in chamomile; binds GABA-A receptors with mild anxiolytic/sedative properties. Direct human trials on isolated apigenin are lacking; evidence primarily from chamomile extract RCTs.
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9 of 10 RCTs found chamomile extract effective for anxiety reduction. Long-term chamomile (26 weeks) significantly reduced GAD symptom relapse vs. placebo. Apigenin is a primary active constituent binding the benzodiazepine site of GABA-A receptors.
Dietary apigenin intake inversely associated with inadequate sleep quality (OR 0.63, 95% CI 0.44–0.90); large US cohort also found positive correlation between apigenin intake & sleep quality.
Stacks containing Apigenin
Public community stacks that include this ingredient.
Sleep & Recovery Stack
Designed to support sleep quality, parasympathetic activation, & overnight recovery without heavy sedation.
Sleep Quality & Relaxation
GABA & apigenin are combined to improve sleep quality & promote relaxation. GABA is a neurotransmitter that induces calmness, while apigenin has sedative effects that enhance sleep.
Your personalized stack
Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.
Sleep & Calm Wind-Down
Supports parasympathetic activation before sleep.