The evidence for Vitex agnus-castus includes moderate-quality meta-analyses and RCTs showing symptom relief for PMS. However, the variability in product extracts and standardization is a notable gap that may affect outcomes.
PMS symptom reductionWomen with PMS · RCTModerate
Placebo-controlled RCT reported improved PMS symptom scores with Vitex preparations; extract standardization matters.
PMS symptom remission — meta-analysis of double-blind RCTsWomen with PMS · Meta-analysis of double-blind RCTsModerate
Meta-analysis of 3 high-quality double-blind RCTs (n=520) meeting CONSORT criteria found women taking Vitex agnus-castus were 2.57 times more likely to experience PMS symptom remission vs placebo (OR 2.57, 95% CI 1.52–4.35). Majority of trials are excluded due to incomplete reporting.
Your personalized stack
Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.
PMS Calmer (Low-Stim, Cycle-Friendly)
Cycle-phase support focused on calm & sleep quality without stimulants.
This stack addresses the key nutritional & hormonal drivers of female fertility. Folate is essential for DNA synthesis & embryo development. Myo-inositol is the most evidence-backed intervention for improving ovarian function, egg quality, & cycle regularity — particularly in PCOS. CoQ10 restores mitochondrial energy in aging oocytes, & Vitex supports luteal phase adequacy through LH modulation.
Forms & usage▾
Take standardized extract daily, ideally in the morning. Follow product instructions for dosage.