Athletic Performance and Muscle Growth

B84· Mostly solid

Public • 20 Apr 2026

Combining Ecdysterone with Leucine can enhance athletic performance and support muscle growth. Ecdysterone is an anabolic agent that promotes muscle growth, while Leucine is a key amino acid for muscle protein synthesis.

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Athletic Performance and Muscle Growth

performance muscle-growth strength

Ecdysterone (Beta-Ecdysterone)

30 min pre-workout

MODERATE

500mg

L-Leucine

30 min pre-workout

MODERATE

3000mg

No interactions detected

Each dose includes evidence rationale · doses personalized to your weight

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Supplements

Training load

Unknown

No flags

No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis

Pharmacokinetic + pair-level checks

Timing optimizations

Ecdysterone (Beta-Ecdysterone)

Take ~2h before the intended effect window

Reaches peak plasma concentration in ~2h. Half-life ~9h.

L-Leucine

Take ~1h before the intended effect window

Reaches peak plasma concentration in ~1h. Half-life ~2.5h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements

2 items

Ecdysterone (Beta-Ecdysterone)Very low

30 min pre-workout •

Ecdysterone is an anabolic agent that promotes muscle growth.

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500mg

Muscle protein synthesis

Very low

Population: General population

Study type: Theoretical

Dose context: 500 mg typical (range: 500–1000 mg)

Ecdysterone is believed to enhance muscle protein synthesis via the mTOR/PI3K pathway.

Citation: No specific citation available.

Mechanistic insights suggest potential benefits for muscle growth.

Lean mass gain

Moderate

Population: Trained athletes

Study type: RCT

Dose context: 500 mg typical (range: 500–500 mg) • Duration: 10 weeks

Significant increases in lean mass were observed in athletes taking ecdysterone compared to placebo.

Citation: No specific citation available.

Study showed promising results for muscle growth without androgenic effects.

Muscle strength improvement

Moderate

Population: Trained athletes

Study type: RCT

Dose context: 500 mg typical (range: 500–500 mg) • Duration: 10 weeks

Athletes experienced significant improvements in muscle strength.

Citation: No specific citation available.

Strength gains were noted without any reported side effects.

L-LeucineLow

30 min pre-workout •

Leucine is a key amino acid for muscle protein synthesis.

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3000mg

anemia improvement

Low

Population: patients with transfusion-dependent Diamond-Blackfan anemia

Study type: Cohort

Dose context: 3000 mg typical • Duration: Phase I/II study

L-leucine improved anemia and growth in patients with Diamond-Blackfan anemia.

Citation: Vlachos et al. (2020). L-leucine improves anemia and growth in patients with transfusion-dependent Diamond-Blackfan anemia.•DOI: 10.1002/pbc.28748

quality of life improvement

Moderate

Population: patients with Niemann-Pick disease type C

Study type: RCT

Dose context: 4000 mg typical (range: 4000–4000 mg) • Duration: 6 weeks

N-acetyl-L-leucine improved symptoms and quality of life in Niemann-Pick disease type C patients.

Citation: Beyraghi-Tousi et al. (2024). Efficacy and safety of N-acetyl-L-leucine in patients with ataxia telangiectasia.•DOI: 10.1016/j.ejpn.2024.04.009

muscle protein synthesis

Moderate

Population: untrained midlife women

Study type: RCT

Dose context: 3000 mg typical (range: 3000–3000 mg) • Duration: 12 weeks

L-leucine supplementation coupled with resistance training improved muscle protein synthesis.

Citation: Funderburk et al. (2020). Efficacy of L-leucine Supplementation Coupled With Resistance Training in Untrained Midlife Women.•DOI: 10.1080/07315724.2019.1650675