Gut Health and Anti-inflammatory Support

B84· Mostly solid

Public • 20 Apr 2026

Combining Butyrate with Turmeric can support gut health and reduce inflammation. Butyrate is a short-chain fatty acid that supports gut barrier function, while Turmeric is known for its anti-inflammatory properties.

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Gut Health and Anti-inflammatory Support

gut-health anti-inflammatory immune

Sodium Butyrate

Daily with meals

MODERATE

600mg

Curcumin Extract

Daily with meals

MODERATE

500mg

No interactions detected

Each dose includes evidence rationale · doses personalized to your weight

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Clean

Supplements

Training load

Unknown

No flags

No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis

Pharmacokinetic + pair-level checks

Timing optimizations

Sodium Butyrate

Take ~2h before the intended effect window

Reaches peak plasma concentration in ~2h. Half-life ~0.5h.

Curcumin Extract

Take ~2h before the intended effect window

Reaches peak plasma concentration in ~2h. Half-life ~8h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements

2 items

Sodium ButyrateModerate

Daily with meals •

Butyrate supports gut barrier function.

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600mg

Abdominal pain frequency

Moderate

Population: Patients with irritable bowel syndrome

Study type: RCT

Dose context: 600 mg typical

Microencapsulated sodium butyrate reduced the frequency of abdominal pain in IBS patients.

Citation: Banasiewicz et al. (2013). Microencapsulated sodium butyrate reduces the frequency of abdominal pain in patients with irritable bowel syndrome. Controlled Clinical Trials.•DOI: 10.1111/j.1463-1318.2012.03152.x

BMI reduction

Moderate

Population: Children with obesity

Study type: RCT

Dose context: 600 mg typical • Duration: 6 months

Butyrate supplementation resulted in a significant reduction in BMI in children with obesity.

Citation: Mitrović et al. (2025). Exploring the Potential of Oral Butyrate Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: Subgroup Insights from an Interventional Study. Gut.•DOI: 10.20944/preprints202504.0157.v1

Gut microbiota composition

Moderate

Population: Patients with inflammatory bowel disease

Study type: RCT

Dose context: 600 mg typical • Duration: 2 months

Sodium butyrate altered the gut microbiota by increasing bacteria able to produce SCFA, improving quality of life in ulcerative colitis patients.

Citation: van der Beek et al. (2015). Hepatic Uptake of Rectally Administered Butyrate Prevents an Increase in Systemic Butyrate Concentrations in Humans. Croatian Medical Journal.•DOI: 10.3945/jn.115.211193

Curcumin ExtractModerate

Daily with meals •

Turmeric is known for its anti-inflammatory properties.

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500mg

Delayed-onset muscle soreness (DOMS) reduction after exercise

Moderate

Population: Healthy adults performing resistance or eccentric exercise

Study type: Systematic review and meta-analysis of RCTs

Dose context: —

Curcumin supplementation significantly reduced DOMS & muscle damage markers (CK, LDH) vs placebo; effect sizes were moderate & clinically meaningful for pain reduction in eccentric exercise protocols.

Citation: Beba M, et al. The effect of curcumin supplementation on delayed-onset muscle soreness, inflammation, muscle strength, and joint flexibility: a systematic review and dose-response meta-analysis of randomized controlled trials. Phytother Res. 2022;36(7):2739-2753.•https://pubmed.ncbi.nlm.nih.gov/35574627/

Systemic inflammation — CRP & high-sensitivity CRP reduction

Moderate

Population: Adults with pro-inflammatory conditions (various clinical populations)

Study type: Systematic review and meta-analysis of RCTs

Dose context: 1000 mg typical • Duration: >10 weeks

Curcumin supplementation significantly decreased CRP (WMD −3.67 mg/L, 95% CI −6.96 to −0.38) & hs-CRP vs placebo across 9 CRP & 23 hs-CRP trials; greatest effect at doses ≤1,000 mg/day & duration >10 weeks.

Citation: Gorabi AM, Abbasifard M, Imani D, et al. Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials. Phytother Res. 2022;36(1):85-97.•DOI: 10.1002/ptr.7284•https://pubmed.ncbi.nlm.nih.gov/34586711/

Non-linear dose-response; stronger effects with <2,000 mg/day curcumin.

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