StackTerminal.Health

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Gut Health and Anti-inflammatory Support

B84· Mostly solid
Public • 20 Apr 2026

Combining Shiitake Mushroom with Lactoferrin can support gut health and reduce inflammation. Shiitake Mushroom is known for its immune-boosting and anti-inflammatory properties, while Lactoferrin provides antimicrobial and gut health support.

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Gut Health and Anti-inflammatory Support
gut-healthanti-inflammatoryimmune
Shiitake Mushroom
Daily with meals
MODERATE
1500mg
Lactoferrin
Daily with meals
MODERATE
200mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
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Clean
Supplements
2
Training load
Unknown
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No duplication, stimulant, interaction, or recovery concerns detected.

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Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Lactoferrin
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~8h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
Shiitake MushroomModerate
Daily with meals •
Shiitake Mushroom is known for its immune-boosting and anti-inflammatory properties.
Buy ingredient →
1500mg
immune function
Moderate
Population: cancer patients
Study type: Systematic review
Dose context: 1500 mg typical

Lentinan, a polysaccharide from Shiitake mushrooms, has been shown to activate immunocytes through multiple signaling pathways.

Citation: Zhang et al. (2019). Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China. Progress in Molecular Biology and Translational Science.•DOI: 10.1016/bs.pmbts.2019.02.013
immune function
Low
Population: rodent model of pulmonary sepsis
Study type: RCT
Dose context: 1500 mg typical

Purified β-glucans from Shiitake mushrooms reduced infection by a multidrug-resistant strain of Klebsiella pneumoniae, likely through immunomodulation.

Citation: Masterson et al. (2020). Purified β-glucans from the Shiitake mushroom ameliorates antibiotic-resistant Klebsiella pneumoniae-induced pulmonary sepsis. Letters in Applied Microbiology.•DOI: 10.1111/lam.13358
immune function
Moderate
Population: HIV-positive patients
Study type: RCT
Dose context: 1500 mg typical • Duration: 8-12 weeks

Lentinan demonstrated immune modulating properties in HIV-positive patients.

Citation: Gordon et al. (1998). A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: a phase I/II trial.
LactoferrinModerate
Daily with meals •
Lactoferrin provides antimicrobial and gut health support.
Buy ingredient →
200mg
Immune function
Moderate
Population: Humans
Study type: Systematic review and Meta-analysis
Dose context: 200 mg typical

Lactoferrin supplementation was associated with improved immune function & a decrease in systemic inflammatory biomarkers.

Citation: Berthon et al. (2022). Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis. Clinical Infectious Diseases.•DOI: 10.1093/advances/nmac047
Acne vulgaris
Moderate
Population: Women with mild to moderate acne
Study type: Randomized clinical trial
Dose context: 200 mg typical

Lactoferrin, in combination with vitamin E & zinc, was effective in reducing acne severity.

Citation: Chan et al. (2017). A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris.•DOI: 10.1111/ijd.13607
Iron-deficiency anemia
Moderate
Population: Children with inflammatory bowel disease
Study type: Clinical trial
Dose context: 200 mg typical

Lactoferrin was effective in improving iron status in children with inflammatory bowel disease.

Citation: El Amrousy et al. (2022). Lactoferrin for iron-deficiency anemia in children with inflammatory bowel disease: a clinical trial.•DOI: 10.1038/s41390-022-02136-2

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