Sodium Butyrate
Sodium butyrate is a short-chain fatty acid supplement that supports gut health by reinforcing gut barrier integrity and modulating immune function. It shows promise in managing conditions like inflammatory bowel disease and irritable bowel syndrome.
Evidence last reviewed: 20 Apr 2026
The evidence for sodium butyrate is moderate, showing benefits in gut health and conditions like IBS and ulcerative colitis. However, studies on blood pressure and obesity are less robust, indicating a need for further research.
Blood pressurePatients with hypertension · RCTLow
Oral butyrate supplementation showed potential in reducing blood pressure in hypertensive patients.
Abdominal pain frequencyPatients with irritable bowel syndrome · RCTModerate
Microencapsulated sodium butyrate reduced the frequency of abdominal pain in IBS patients.
Remission inductionPatients with mild-to-moderate ulcerative colitis · RCTModerate
Microencapsulated sodium butyrate as add-on therapy was effective in inducing remission in ulcerative colitis patients.
BMI reductionChildren with obesity · RCTModerate
Butyrate supplementation resulted in a significant reduction in BMI in children with obesity.
Gut microbiota compositionPatients with inflammatory bowel disease · RCTModerate
Sodium butyrate altered the gut microbiota by increasing bacteria able to produce SCFA, improving quality of life in ulcerative colitis patients.
Gut Health and Anti-inflammatory Support
Combining Butyrate with Turmeric can support gut health and reduce inflammation. Butyrate is a short-chain fatty acid that supports gut barrier function, while Turmeric is known for its anti-inflammatory properties.
Forms & usage▾
Take 300-600 mg daily, preferably with meals.