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Cognitive & Neuroprotection Support

Public • 06 Apr 2026

Pyrroloquinoline quinone (PQQ) & methylene blue are combined to support cognitive function & provide neuroprotection. PQQ supports mitochondrial function & cognitive performance, while methylene blue enhances mitochondrial function & provides neuroprotective benefits.

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Cognitive & Neuroprotection Support
cognitiveneuroprotectionfocus
Pyrroloquinoline Quinone (PQQ)
Daily with food
MODERATE
20mg
Methylene Blue
Daily with food
MODERATE
2mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
AI risk assessment
Context: No wearable data
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Stack pre-check
No personal data connected — connect wearables or upload bloodwork for a personalised check
Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Pyrroloquinoline Quinone (PQQ)
Take ~2h before the intended effect window
Reaches peak plasma concentration in ~2h. Half-life ~3h.
Methylene Blue
Take ~1h before the intended effect window
Reaches peak plasma concentration in ~1h. Half-life ~5h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
Pyrroloquinoline Quinone (PQQ)Moderate
Daily with food •
Supports mitochondrial function & cognitive performance.
Buy ingredient →
20mg
cognitive function
Moderate
Population: healthy volunteers
Study type: RCT
Dose context: 21 mg typical (range: 21–21 mg) • Duration: 12 weeks

PQQ supplementation improved cognitive performance, including memory & attention, in healthy elderly individuals.

Citation: Baltic et al. (2024). The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial. Journal of Nutrition, Health & Aging.•DOI: 10.1016/j.jnha.2024.100287
cognitive function
Moderate
Population: middle-aged to elderly individuals
Study type: RCT
Dose context: 20 mg typical (range: 20–20 mg) • Duration: 12 weeks

PQQ supplementation was found to improve memory, attention, & cognitive function in individuals experiencing age-related cognitive decline.

Citation: Itoh et al. (2016). Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions. JAMA Neurology.•DOI: 10.1001/jamaneurol.2022.3543
aerobic exercise performance
Low
Population: untrained men
Study type: RCT
Dose context: 20 mg typical (range: 20–20 mg) • Duration: 6 weeks

PQQ supplementation may enhance aerobic exercise performance & mitochondrial biogenesis in untrained individuals.

Citation: Hwang et al. (2020). Effects of Pyrroloquinoline Quinone (PQQ) Supplementation on Aerobic Exercise Performance and Indices of Mitochondrial Biogenesis in Untrained Men. Journal of the American College of Nutrition.•DOI: 10.1080/07315724.2019.1705203
Methylene BlueLow
Daily with food •
Enhances mitochondrial function & provides neuroprotective benefits.
Buy ingredient →
2mg
Mortality reduction
Low
Population: Critically ill and perioperative patients
Study type: Meta-analysis
Dose context: 2 mg typical

Methylene Blue may reduce mortality in critically ill & perioperative patients.

Citation: Pruna et al. (2024). Methylene Blue Reduces Mortality in Critically Ill and Perioperative Patients: A Meta-Analysis of Randomized Trials. New England Journal of Medicine.•DOI: 10.1056/NEJMra1208623
Hospital length of stay
Low
Population: Patients with septic shock
Study type: Systematic review
Dose context: 2 mg typical

Methylene Blue may reduce hospital length of stay in patients with septic shock.

Citation: Rotella et al. (2020). Treatment for beta-blocker poisoning: a systematic review. Clinical Toxicology.•DOI: 10.1080/15563650.2020.1752918
Cognitive enhancement
Very low
Population: General population
Study type: Theoretical
Dose context: 2 mg typical (range: 2–10 mg)

Methylene Blue is theorized to enhance cognitive function through its role as a mitochondrial electron shuttle.

Citation: Based on known pharmacology.
No direct clinical evidence available.
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