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Pyrroloquinoline Quinone (PQQ)

Pyrroloquinoline Quinone (PQQ) is a redox cofactor that supports mitochondrial biogenesis & provides antioxidant protection, with preliminary evidence suggesting benefits for cognitive function & energy metabolism.

energycognitiveantioxidantmitochondrial

Evidence last reviewed: 05 Apr 2026

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Evidence
4 records
4 recordsBest grade:Moderate
Biomarkers
Cognitive FunctionMemoryAerobic CapacityOxidative Stress (MDA)

The evidence for PQQ includes moderate support for cognitive improvements and potential benefits for exercise performance and oxidative stress reduction. However, the overall strength of the studies varies, and more robust research is needed to fully understand its effects.

oxidative stress markers
elderly individuals · Pilot Study
Low

PQQ supplementation showed potential in reducing oxidative stress markers in elderly individuals.

Dose: 20 mgDuration: 12 weeksForm: Disodium Salt
Citation: Bosco et al. (2024). Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress-A Pilot Study. Archives of Neurology.
cognitive function
healthy volunteers · RCT
Moderate

PQQ supplementation improved cognitive performance, including memory & attention, in healthy elderly individuals.

Dose: 21 mgDuration: 12 weeksForm: Disodium Salt
Citation: Baltic et al. (2024). The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial. Journal of Nutrition, Health & Aging.
aerobic exercise performance
untrained men · RCT
Low

PQQ supplementation may enhance aerobic exercise performance & mitochondrial biogenesis in untrained individuals.

Dose: 20 mgDuration: 6 weeksForm: Disodium Salt
Citation: Hwang et al. (2020). Effects of Pyrroloquinoline Quinone (PQQ) Supplementation on Aerobic Exercise Performance and Indices of Mitochondrial Biogenesis in Untrained Men. Journal of the American College of Nutrition.
cognitive function
middle-aged to elderly individuals · RCT
Moderate

PQQ supplementation was found to improve memory, attention, & cognitive function in individuals experiencing age-related cognitive decline.

Dose: 20 mgDuration: 12 weeksForm: Disodium Salt
Citation: Itoh et al. (2016). Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions. JAMA Neurology.
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Cognitive & Neuroprotection Support

by@athlete

Pyrroloquinoline quinone (PQQ) & methylene blue are combined to support cognitive function & provide neuroprotection. PQQ supports mitochondrial function & cognitive performance, while methylene blue enhances mitochondrial function & provides neuroprotective benefits.

Pyrroloquinoline Quinone (PQQ)
20mg
Methylene Blue
2mg
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How to take it

Take 10-20 mg daily, preferably with meals.

Disodium Salt
Commonly used in supplements for enhanced stability and absorption.
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