Alternative layoutGrade B · 87Clean with useful synergies

Budget Daily Health Base

Maximizes health impact per dollar.

What this is for

General support

budget, daily, high-roi

Why you are seeing this

Goal fit: budget, daily, high-roi.

What to do next

Add body metrics if you want dose previews to reflect your weight rather than the reference dose.

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Public•Built 28 Jan 2026•2 ingredients•No interactions detected · 1 synergy found

Core stack

The main ingredients doing the work.

2 key items

Vitamin D3Moderate

Daily • Cholecalciferol •

High ROI micronutrient for most adults.

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50mg

Prevention of acute respiratory tract infections

Moderate

Population: Children and adults (ages 0–95); 25 RCTs, n=11,321

Study type: Systematic review and meta-analysis of individual participant data from RCTs

Dose context: —

Vitamin D supplementation reduced risk of acute respiratory tract infection (adjusted OR 0.88, 95% CI 0.81–0.96); greatest benefit in those with baseline deficiency (<25 nmol/L) & those receiving daily or weekly dosing rather than bolus doses.

Citation: Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583.•DOI: 10.1136/bmj.i6583•https://pubmed.ncbi.nlm.nih.gov/28202713/

IPD meta-analysis; high statistical power; effect strongest in vitamin D-deficient individuals.

Vitamin D status & physical performance in athletes

Low

Population: Competitive and recreational athletes

Study type: Narrative review

Dose context: —

Vitamin D insufficiency is prevalent among athletes, particularly indoor athletes & those in northern latitudes in winter. Insufficiency is associated with reduced muscle strength, power, & endurance; supplementation of 2,000–6,000 IU/day recommended to maintain 25(OH)D >40 ng/mL.

Citation: Yoon S, Kwon O, Kim J. Vitamin D in athletes: focus on physical performance and musculoskeletal injuries. Phys Act Nutr. 2021;25(2):20-25.•DOI: 10.20463/pan.2021.0011•https://pubmed.ncbi.nlm.nih.gov/34315203/

Narrative review; prevalence data robust, intervention evidence more limited.

Fracture prevention in elderly adults

Moderate

Population: Ambulatory and institutionalized elderly persons

Study type: Systematic review and meta-analysis of RCTs

Dose context: —

Vitamin D at 700–800 IU/day reduced hip fracture risk by 26% (RR 0.74) & any nonvertebral fracture by 23% (RR 0.77); no significant benefit was observed at 400 IU/day.

Citation: Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005;293(18):2257-64.•DOI: 10.1001/jama.293.18.2257•https://pubmed.ncbi.nlm.nih.gov/15886381/

Dose-dependent effect; 400 IU/day insufficient for fracture prevention.

Magnesium GlycinateModerate

Evening • Glycinate •

Commonly under-consumed mineral.

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400mg

Trade-offs & context

Tolerance

Loose stools at higher doses; glycinate form is better tolerated than citrate or oxide

Context: doses >400mg elemental

Timing

Drowsiness — take in the evening to leverage rather than fight this effect

Sleep quality in adults with poor sleep (magnesium bisglycinate RCT)

Moderate

Population: Adults aged 18–65 with self-reported poor sleep (n=155)

Study type: RCT (double-blind, placebo-controlled)

Dose context: 250 mg typical (range: 200–250 mg) • Duration: 8 weeks

250 mg elemental magnesium as bisglycinate modestly but significantly reduced Insomnia Severity Index score vs. placebo (−3.9 vs −2.3, p=0.049) by week 4; well-tolerated with minimal GI effects.

Citation: Abboud M et al. Nutrients. 2025.•https://pubmed.ncbi.nlm.nih.gov/40918053/

First RCT specifically using magnesium bisglycinate for sleep in a general adult population.

Insomnia in older adults (sleep latency, total sleep time)

Low

Population: Older adults with insomnia (3 RCTs, n=151)

Study type: Systematic review & meta-analysis

Dose context: 320 mg typical (range: 100–500 mg) • Duration: 8 weeks

Magnesium supplementation reduced sleep onset latency by ~17 min vs. placebo; increased sleep time & efficiency. Evidence rated low-to-very-low quality; all trials at moderate-to-high bias risk.

Citation: Mah J & Pitre T. BMC Complement Med Ther. 2021;21(1):125.•DOI: 10.1186/s12906-021-03297-z•https://pubmed.ncbi.nlm.nih.gov/33865376/

Benefit most plausible in those with low baseline magnesium. Dose refers to elemental magnesium.

Stack pre-check

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Clean

Supplements

Training load

Unknown

No flags

No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis

Pharmacokinetic + pair-level checks

1 synergyNo conflicts

Synergies detected

Synergy

Magnesium + Vitamin D3: activation synergyPMID:29480918

Magnesium is required for every enzymatic step that converts inactive vitamin D to its active form (calcitriol). Without adequate magnesium, high-dose D3 supplementation is inefficient. Up to 50% of people are magnesium-insufficient.

→Ensure magnesium intake (300–400mg) when supplementing D3 > 2000 IU.

Timing optimizations

Vitamin D3

With largest fat-containing meal

Fat-soluble. Co-ingestion with dietary fat increases absorption by 32–56%. (Onset: ~12h, half-life: ~360h)

Magnesium Glycinate

Evening (glycinate/threonate) or before bed

Magnesium promotes GABA activity and lowers core body temperature, aiding sleep onset and quality. (Onset: ~2h, half-life: ~8h)

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.