StackTerminal.Health

BETA

Creatine Monohydrate

Supports high-intensity performance & lean mass; among the best-studied sports supplements.

micro:cognitivemicro:endurancemicro:energy-fatiguemicro:focus-cognitionmicro:focus-cognitivemicro:performancemicro:powermicro:recoverymicro:strength
Evidence last reviewed: 20 Apr 2026
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Trade-offs & context
Known concerns, timing considerations, & interactions
Tolerance

Water retention of 1–2 kg in the first week (intramuscular, not fat)

Tolerance

GI discomfort — bloating and cramping; spread loading doses across the day

Context: loading phase >10g/day

Note

Non-responders (~25–30%) see minimal benefit regardless of dose

Dot colour: High concern  Moderate   Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
MemoryCognitive Function
Performance
Muscle Strength (1RM)Power Output
Evidence
2 records
Short-term memory & reasoning
Healthy adults (6 RCTs, n=281); larger effects in older adultsSystematic review of RCTs
PUBMEDModerate

Oral creatine may improve short-term memory & intelligence/reasoning in healthy individuals; effect on other cognitive domains unclear.

Dose: 5000 mgDuration: 4–12 weeks
Cognitive benefits most consistent in aging or sleep-deprived populations & those with lower dietary creatine (e.g., vegetarians).
Strength / power performance
Healthy adults; athletes and recreationally trainedISSN Position Stand (comprehensive review)
PUBMEDHigh

Consistent improvements in strength, power, & training volume; safe for long-term use (up to 30 g/day for 5 years studied). Loading optional; maintenance commonly 3–5 g/day.

Dose: 5000 mgDuration: 4–12+ weeks
Non-responders (~25–30%) exist; vegetarians/vegans tend to show larger gains.
Forms
Creatine monohydrate
Most studied; good value; stable.

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Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.

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strengthconstraints

Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.

Beta-Alanine
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Creatine Monohydrate
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strength

High-evidence strength support without grey-area ingredients.

Creatine Monohydrate
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endurance

Based on your goals & preferences, here is a starting stack you can edit.

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