StackTerminal.Health

BETA

Coenzyme Q10

Endogenous antioxidant & mitochondrial cofactor with evidence in heart failure & statin-induced myopathy.

cardiolongevitymitochondrial
Evidence last reviewed: 04 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Performance
Muscle Strength (1RM)
Recovery
DOMS / Muscle SorenessCreatine Kinase (CK)
Evidence
2 records
Morbidity & mortality in chronic heart failure
Adults with moderate-to-severe chronic heart failureRandomized double-blind placebo-controlled trial (Q-SYMBIO)
PUBMEDModerate

CoQ10 100 mg three times daily over 2 years reduced major adverse cardiovascular events (15% vs 26% placebo) & all-cause mortality (10% vs 18% placebo; RR 0.58, 95% CI 0.35–0.95) in addition to standard therapy.

Dose: 300 mgDuration: 2 years
Landmark RCT; conducted in patients on background heart failure therapy.
Statin-associated muscle symptoms (myalgia, weakness, cramps)
Adults experiencing statin-induced myopathySystematic review and meta-analysis of RCTs
PUBMEDLow

CoQ10 supplementation significantly improved statin-associated muscle pain (WMD −1.60), weakness (WMD −2.28), cramps (WMD −1.78), & tiredness (WMD −1.75) across 12 RCTs (n=575), though plasma creatine kinase was not significantly reduced.

Dose:
Symptom improvement without biochemical marker change; overall evidence quality is low due to small trial sizes.
Forms
Ubiquinol or ubiquinone
Ubiquinol may have better absorption in older adults.

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