StackTerminal.Health

BETA

Berberine

Alkaloid from Berberis plants with evidence for glycemic control & lipid improvement.

metabolic-healthlongevity
Evidence last reviewed: 04 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
LDL CholesterolTriglyceridesHDL Cholesterol
Metabolic
Blood GlucoseHbA1c
Evidence
2 records
Dyslipidemia — LDL, triglycerides, total cholesterol
Adults with dyslipidemiaSystematic review and meta-analysis of RCTs
PUBMEDModerate

Berberine reduced LDL cholesterol by 0.46 mmol/L, triglycerides by 0.34 mmol/L, & total cholesterol by 0.48 mmol/L across 18 RCTs; HDL changes differed by sex (increase in women, slight decrease in men). No serious adverse events reported.

Dose: 900–1500 mgDuration: 4–24 weeks
Glycemic control in type 2 diabetes
Adults with type 2 diabetesSystematic review and meta-analysis of RCTs
PUBMEDModerate

Berberine reduced fasting plasma glucose by 0.82 mmol/L, HbA1c by 0.63%, & 2-hour postprandial glucose by 1.16 mmol/L across 37 RCTs (n=3048); glucose-lowering effect correlated with baseline glucose levels.

Dose: 500–1500 mgDuration: 8–24 weeks
Forms
Berberine HCl
Most studied form.

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