Lactoferrin
Lactoferrin is an iron-binding glycoprotein from milk with antimicrobial, immunomodulatory, & anti-inflammatory properties, beneficial for gastrointestinal infections, iron deficiency anemia, & acne.
Evidence last reviewed: 05 Apr 2026
The evidence for lactoferrin is moderate, showing effectiveness in acne reduction, immune function improvement, and iron status enhancement in specific populations. However, more extensive research is needed to fully establish its benefits across broader demographics.
Acne vulgarisWomen with mild to moderate acne · Randomized clinical trialModerate
Lactoferrin, in combination with vitamin E & zinc, was effective in reducing acne severity.
Iron-deficiency anemiaChildren with inflammatory bowel disease · Clinical trialModerate
Lactoferrin was effective in improving iron status in children with inflammatory bowel disease.
Prevention of necrotizing enterocolitisPreterm infants · Systematic review and Meta-analysisModerate
Lactoferrin, in combination with probiotics, was effective in reducing the incidence of necrotizing enterocolitis in preterm infants.
Immune functionHumans · Systematic review and Meta-analysisModerate
Lactoferrin supplementation was associated with improved immune function & a decrease in systemic inflammatory biomarkers.
Gut Health and Anti-inflammatory Support
Combining Shiitake Mushroom with Lactoferrin can support gut health and reduce inflammation. Shiitake Mushroom is known for its immune-boosting and anti-inflammatory properties, while Lactoferrin provides antimicrobial and gut health support.
Forms & usage▾
Take 250-500 mg daily, preferably with meals.