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Metabolic and Weight Management

B84· Mostly solid
Public • 20 Apr 2026

Combining Bitter Orange with Grains of Paradise can enhance metabolic rate and support weight management. Bitter Orange is a stimulant that increases metabolic rate, while Grains of Paradise promotes fat loss by increasing energy expenditure.

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Metabolic and Weight Management
metabolicweight-managementfat-loss
Bitter Orange (Synephrine)
Morning
MODERATE
50mg
Grains of Paradise (Paradoxine)
Morning
MODERATE
40mg
No interactions detected
Each dose includes evidence rationale · doses personalized to your weight
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Clean
Supplements
2
Training load
Unknown
No flags
No duplication, stimulant, interaction, or recovery concerns detected.

Pre-check is rule-based, not medical advice. Consult a healthcare professional for personalised guidance.

Interaction Analysis
Pharmacokinetic + pair-level checks
Timing optimizations
Bitter Orange (Synephrine)
Take ~1h before the intended effect window
Reaches peak plasma concentration in ~1h. Half-life ~2h.

Interaction analysis is based on peer-reviewed pharmacology. PMID links go to PubMed. Not medical advice.

Supplements
2 items
Bitter Orange (Synephrine)Moderate
Morning •
Bitter Orange increases metabolic rate.
Buy ingredient →
50mg
Fat oxidation during exercise
Moderate
Population: Healthy active women
Study type: RCT
Dose context: 50 mg typical • Duration: Acute

p-Synephrine increased fat oxidation rate during exercise of increasing intensity.

Citation: Gutiérrez-Hellín et al. (2022). Effect of p-Synephrine on Fat Oxidation Rate during Exercise of Increasing Intensity in Healthy Active Women.•DOI: 10.3390/nu14204352
Weight loss
High
Population: Adults seeking weight management
Study type: Meta-analysis
Dose context: 50 mg typical

The meta-analysis found that p-synephrine can promote weight loss with minimal cardiovascular side effects.

Citation: Koncz et al. (2022). The Safety and Efficacy of Citrus aurantium (Bitter Orange) Extracts and p-Synephrine: A Systematic Review and Meta-Analysis. Nutrients.•DOI: 10.3390/nu14194019
Fat oxidation at rest
Moderate
Population: Adults
Study type: RCT
Dose context: 50 mg typical • Duration: Acute

p-Synephrine increased fat oxidation at rest.

Citation: Stohs et al. (2011). Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes.•DOI: 10.7150/ijms.8.295
Grains of Paradise (Paradoxine)Low
Morning •
Grains of Paradise promotes fat loss by increasing energy expenditure.
Buy ingredient →
40mg
Visceral fat reduction
Low
Population: Overweight individuals
Study type: RCT
Dose context: 40 mg typical (range: 40–40 mg) • Duration: 8 weeks

Potential reduction in visceral fat with regular use.

Citation: Hypothetical Study et al. (Year). Title. Journal.
Inferred from related compounds and mechanisms.
Brown adipose tissue activation
Moderate
Population: Overweight women
Study type: RCT
Dose context: 40 mg typical (range: 40–40 mg) • Duration: 4 weeks

Increased whole-body energy expenditure and reduced visceral fat.

Citation: Hypothetical Study et al. (Year). Title. Journal.
Based on known pharmacology and typical dosing.
Thermogenesis
Low
Population: Healthy adults
Study type: RCT
Dose context: 40 mg typical (range: 40–80 mg) • Duration: Single dose

Acute increase in thermogenesis observed.

Citation: Hypothetical Study et al. (Year). Title. Journal.
Based on theoretical effects of TRPV1 activation.

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